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Overexpression of Rev1 promotes the development of carcinogen-induced intestinal adenomas via accumulation of point mutation and suppression of apoptosis proportionally to the Rev1 expression level
Cancer development often involves mutagenic replication of damaged DNA by the error-prone translesion synthesis (TLS) pathway. Aberrant activation of this pathway plays a role in tumorigenesis by promoting genetic mutations. Rev1 controls the function of the TLS pathway, and Rev1 expression levels a...
Autores principales: | Sasatani, Megumi, Xi, Yang, Kajimura, Junko, Kawamura, Toshiyuki, Piao, Jinlian, Masuda, Yuji, Honda, Hiroaki, Kubo, Kei, Mikamoto, Takahiro, Watanabe, Hiromitsu, Xu, Yanbin, Kawai, Hidehiko, Shimura, Tsutomu, Noda, Asao, Hamasaki, Kanya, Kusunoki, Yoichiro, Zaharieva, Elena Karamfilova, Kamiya, Kenji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872566/ https://www.ncbi.nlm.nih.gov/pubmed/28498946 http://dx.doi.org/10.1093/carcin/bgw208 |
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