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Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract
The aim of this study was to evaluate the potentials of fermented Cucurbita moschata extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD). Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872621/ https://www.ncbi.nlm.nih.gov/pubmed/29725353 http://dx.doi.org/10.1155/2018/3908453 |
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author | Hossain, Md. Akil Lee, Seung-Jin Park, Na-Hye Birhanu, Biruk Tesfaye Mechesso, Abraham Fikru Park, Ji-Yong Park, Eun-Jin Lee, Sam-Pin Youn, Sun-Joo Park, Seung-Chun |
author_facet | Hossain, Md. Akil Lee, Seung-Jin Park, Na-Hye Birhanu, Biruk Tesfaye Mechesso, Abraham Fikru Park, Ji-Yong Park, Eun-Jin Lee, Sam-Pin Youn, Sun-Joo Park, Seung-Chun |
author_sort | Hossain, Md. Akil |
collection | PubMed |
description | The aim of this study was to evaluate the potentials of fermented Cucurbita moschata extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD). Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat diet (HFD) with and without FCME. Changes in body weight gain and consumption of feed and water were recorded. Major organs, adipose tissues, and blood samples were collected after the experimental period. The serum lipid profile, histological features of liver and adipose tissues, and mRNA expression of different adipogenic/lipogenic genes from liver tissue were evaluated. The supplementation of FCME in HFD significantly prevented HFD-induced increment of bodyweight. The adipose tissue mass, liver enzymes, and plasma lipids were also reduced significantly (p < 0.05) by the consumption of FCME. The mRNA expressions of adipogenic/lipogenic genes (PPARγ, C/EBPα, C/EBP(β), C/EBPγ, and SREBP-1C) in FCME-treated obese mice were considerably (p < 0.05) suppressed. FCME showed its antiobesity potential by suppressing the body weight gain and by modulating the plasma lipids and liver enzymes through the regulation of adipogenic/lipogenic transcriptional factors. Fermented Cucurbita moschata could be an opportunistic agent in controlling obesity and fatty liver changes. |
format | Online Article Text |
id | pubmed-5872621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58726212018-05-03 Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract Hossain, Md. Akil Lee, Seung-Jin Park, Na-Hye Birhanu, Biruk Tesfaye Mechesso, Abraham Fikru Park, Ji-Yong Park, Eun-Jin Lee, Sam-Pin Youn, Sun-Joo Park, Seung-Chun Evid Based Complement Alternat Med Research Article The aim of this study was to evaluate the potentials of fermented Cucurbita moschata extract (FCME) in the treatment of obesity and nonalcoholic fatty liver disease (NAFLD). Five-week-old male C57BL/6 mice were assigned to 6 groups and treated for 8 weeks by feeding the normal diet (ND) and high fat diet (HFD) with and without FCME. Changes in body weight gain and consumption of feed and water were recorded. Major organs, adipose tissues, and blood samples were collected after the experimental period. The serum lipid profile, histological features of liver and adipose tissues, and mRNA expression of different adipogenic/lipogenic genes from liver tissue were evaluated. The supplementation of FCME in HFD significantly prevented HFD-induced increment of bodyweight. The adipose tissue mass, liver enzymes, and plasma lipids were also reduced significantly (p < 0.05) by the consumption of FCME. The mRNA expressions of adipogenic/lipogenic genes (PPARγ, C/EBPα, C/EBP(β), C/EBPγ, and SREBP-1C) in FCME-treated obese mice were considerably (p < 0.05) suppressed. FCME showed its antiobesity potential by suppressing the body weight gain and by modulating the plasma lipids and liver enzymes through the regulation of adipogenic/lipogenic transcriptional factors. Fermented Cucurbita moschata could be an opportunistic agent in controlling obesity and fatty liver changes. Hindawi 2018-03-13 /pmc/articles/PMC5872621/ /pubmed/29725353 http://dx.doi.org/10.1155/2018/3908453 Text en Copyright © 2018 Md. Akil Hossain et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hossain, Md. Akil Lee, Seung-Jin Park, Na-Hye Birhanu, Biruk Tesfaye Mechesso, Abraham Fikru Park, Ji-Yong Park, Eun-Jin Lee, Sam-Pin Youn, Sun-Joo Park, Seung-Chun Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title_full | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title_fullStr | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title_full_unstemmed | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title_short | Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Cucurbita moschata Extract |
title_sort | enhancement of lipid metabolism and hepatic stability in fat-induced obese mice by fermented cucurbita moschata extract |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872621/ https://www.ncbi.nlm.nih.gov/pubmed/29725353 http://dx.doi.org/10.1155/2018/3908453 |
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