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Genome Editing Redefines Precision Medicine in the Cardiovascular Field

Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enorm...

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Autores principales: Dzilic, Elda, Lahm, Harald, Dreßen, Martina, Deutsch, Marcus-André, Lange, Rüdiger, Wu, Sean M., Krane, Markus, Doppler, Stefanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872631/
https://www.ncbi.nlm.nih.gov/pubmed/29731778
http://dx.doi.org/10.1155/2018/4136473
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author Dzilic, Elda
Lahm, Harald
Dreßen, Martina
Deutsch, Marcus-André
Lange, Rüdiger
Wu, Sean M.
Krane, Markus
Doppler, Stefanie A.
author_facet Dzilic, Elda
Lahm, Harald
Dreßen, Martina
Deutsch, Marcus-André
Lange, Rüdiger
Wu, Sean M.
Krane, Markus
Doppler, Stefanie A.
author_sort Dzilic, Elda
collection PubMed
description Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies.
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spelling pubmed-58726312018-05-06 Genome Editing Redefines Precision Medicine in the Cardiovascular Field Dzilic, Elda Lahm, Harald Dreßen, Martina Deutsch, Marcus-André Lange, Rüdiger Wu, Sean M. Krane, Markus Doppler, Stefanie A. Stem Cells Int Review Article Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease. Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing. Such tools have enormous potential for basic science as well as for regenerative medicine. Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach. In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field. We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies. Finally, we discuss social and ethical implications of these new technologies. Hindawi 2018-03-14 /pmc/articles/PMC5872631/ /pubmed/29731778 http://dx.doi.org/10.1155/2018/4136473 Text en Copyright © 2018 Elda Dzilic et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dzilic, Elda
Lahm, Harald
Dreßen, Martina
Deutsch, Marcus-André
Lange, Rüdiger
Wu, Sean M.
Krane, Markus
Doppler, Stefanie A.
Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title_full Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title_fullStr Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title_full_unstemmed Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title_short Genome Editing Redefines Precision Medicine in the Cardiovascular Field
title_sort genome editing redefines precision medicine in the cardiovascular field
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872631/
https://www.ncbi.nlm.nih.gov/pubmed/29731778
http://dx.doi.org/10.1155/2018/4136473
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