Cargando…
Corneal Innervation and Sensation: The Eye and Beyond
The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors – all of which combined help to maintain the structural and functional inte...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
YJBM
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872636/ https://www.ncbi.nlm.nih.gov/pubmed/29599653 |
_version_ | 1783309879292723200 |
---|---|
author | Yang, Alina Y. Chow, Jessica Liu, Ji |
author_facet | Yang, Alina Y. Chow, Jessica Liu, Ji |
author_sort | Yang, Alina Y. |
collection | PubMed |
description | The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors – all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, surgery, or trauma can lead to diminished corneal sensitivity, epithelial defects, and possible blindness. In this review, we describe commonly used tools that have provided considerable new information on corneal architecture and sensation in healthy and diseased corneas, with special emphasis on changes seen in herpes zoster ophthalmicus, corneal and other therapeutic ocular procedures, antiglaucoma medical therapy, aging, and diabetes. With its potential applications ranging from managing ocular-specific to systemic diseases, the study of corneal innervation has implications for future therapies extending beyond just the eye itself. |
format | Online Article Text |
id | pubmed-5872636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | YJBM |
record_format | MEDLINE/PubMed |
spelling | pubmed-58726362018-03-29 Corneal Innervation and Sensation: The Eye and Beyond Yang, Alina Y. Chow, Jessica Liu, Ji Yale J Biol Med Review The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors – all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, surgery, or trauma can lead to diminished corneal sensitivity, epithelial defects, and possible blindness. In this review, we describe commonly used tools that have provided considerable new information on corneal architecture and sensation in healthy and diseased corneas, with special emphasis on changes seen in herpes zoster ophthalmicus, corneal and other therapeutic ocular procedures, antiglaucoma medical therapy, aging, and diabetes. With its potential applications ranging from managing ocular-specific to systemic diseases, the study of corneal innervation has implications for future therapies extending beyond just the eye itself. YJBM 2018-03-28 /pmc/articles/PMC5872636/ /pubmed/29599653 Text en Copyright ©2018, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes. |
spellingShingle | Review Yang, Alina Y. Chow, Jessica Liu, Ji Corneal Innervation and Sensation: The Eye and Beyond |
title | Corneal Innervation and Sensation: The Eye and Beyond |
title_full | Corneal Innervation and Sensation: The Eye and Beyond |
title_fullStr | Corneal Innervation and Sensation: The Eye and Beyond |
title_full_unstemmed | Corneal Innervation and Sensation: The Eye and Beyond |
title_short | Corneal Innervation and Sensation: The Eye and Beyond |
title_sort | corneal innervation and sensation: the eye and beyond |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872636/ https://www.ncbi.nlm.nih.gov/pubmed/29599653 |
work_keys_str_mv | AT yangalinay cornealinnervationandsensationtheeyeandbeyond AT chowjessica cornealinnervationandsensationtheeyeandbeyond AT liuji cornealinnervationandsensationtheeyeandbeyond |