Phototransduction in Retinal Ganglion Cells

The mammalian retina contains a small number of retinal ganglion cells that express melanopsin, a retinal based visual pigment, and generate a depolarizing response to light in the absence of rod and cone driven synaptic input; hence they are referred to as intrinsically photosensitive retinal ganglion cells (ipRGCs). They have been shown to be comprised of a number of sub-types and to provide luminance information that participates primarily in a variety of non-imaging forming visual functions. Here I review what is currently known about the cascade of events that couple the photoisomerization of melanopsin to the opening of a non-selective cation channel. While these events conform in a general sense to the prevailing model for invertebrate phototransduction, in which visual pigment signals through a G protein of the G(q) class and a phospholipase C cascade to open a TRPC type ion channel, none of the molecular elements in the melanopsin transduction process have been unequivocally identified. This has given rise to the possibility that the underlying mechanism responsible for intrinsic photosensitivity is not same in all ipRGC sub-types and to the recognition that signal transduction in ipRGCs is more complex than originally thought.