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Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis

Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 5...

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Autores principales: Zheng, Xu, Jia, Bin, Song, Xue, Kong, Qing-You, Wu, Mo-Li, Qiu, Ze-Wen, Li, Hong, Liu, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872697/
https://www.ncbi.nlm.nih.gov/pubmed/29495605
http://dx.doi.org/10.3390/nu10030279
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author Zheng, Xu
Jia, Bin
Song, Xue
Kong, Qing-You
Wu, Mo-Li
Qiu, Ze-Wen
Li, Hong
Liu, Jia
author_facet Zheng, Xu
Jia, Bin
Song, Xue
Kong, Qing-You
Wu, Mo-Li
Qiu, Ze-Wen
Li, Hong
Liu, Jia
author_sort Zheng, Xu
collection PubMed
description Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50 male Sprague-Dawley rats were separated into four groups as Group-1 (5 rats); normally fed; Group-2 (15 rats); DEN/MNU/DHPN treatment only; Group-3 (15 rats) and -4 (15 rats); DEN/MNU/DHPN treatment; followed by resveratrol intragastric (IG) injection and intraperitoneal (IP) injection; respectively; in two-day intervals for 30 weeks. The results revealed that the average resveratrol concentration in thyroid tissues was 1.278 ± 0.419 nmol/g in IG group and 1.752 ± 0.398 nmol/g in IP group. The final body weights of Group-3 and Group-4 were lighter than that (p > 0.05) of Group-1; but heavier than Group-2 (p < 0.05). TC-related lesions (hyperplasia and adenomas) were found in 53.3% of Group-2; 33.3% Group-3 and 26.7% Group-4. Lower serum carcino-embryonic antigen (CEA) and thyroglobulin (Tg) levels; down-regulated expression of IL-6 and cyclooxygenase-2 (COX-2); reduction of NF-κB/p65 nuclear translocation; and elevated IkBα expression were found in the thyroid tissues of Group-3 and Group-4 in comparison with that of Group-2. These results demonstrate that IG and IP administered resveratrol efficiently reduces the frequency and severity of DEN/MNU/DHPN-caused TC-related lesions and would be of values in thyroid tumor prevention.
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spelling pubmed-58726972018-03-30 Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis Zheng, Xu Jia, Bin Song, Xue Kong, Qing-You Wu, Mo-Li Qiu, Ze-Wen Li, Hong Liu, Jia Nutrients Article Thyroid cancer (TC) is the most common endocrine malignancy without reliable preventive agent. Resveratrol possesses in vitro anti-TC activities; while its effect(s) on thyroid tumorigenesis remains unknown. This study aims to address this issue using DEN/MNU/DHPN-induced rat carcinogenesis model. 50 male Sprague-Dawley rats were separated into four groups as Group-1 (5 rats); normally fed; Group-2 (15 rats); DEN/MNU/DHPN treatment only; Group-3 (15 rats) and -4 (15 rats); DEN/MNU/DHPN treatment; followed by resveratrol intragastric (IG) injection and intraperitoneal (IP) injection; respectively; in two-day intervals for 30 weeks. The results revealed that the average resveratrol concentration in thyroid tissues was 1.278 ± 0.419 nmol/g in IG group and 1.752 ± 0.398 nmol/g in IP group. The final body weights of Group-3 and Group-4 were lighter than that (p > 0.05) of Group-1; but heavier than Group-2 (p < 0.05). TC-related lesions (hyperplasia and adenomas) were found in 53.3% of Group-2; 33.3% Group-3 and 26.7% Group-4. Lower serum carcino-embryonic antigen (CEA) and thyroglobulin (Tg) levels; down-regulated expression of IL-6 and cyclooxygenase-2 (COX-2); reduction of NF-κB/p65 nuclear translocation; and elevated IkBα expression were found in the thyroid tissues of Group-3 and Group-4 in comparison with that of Group-2. These results demonstrate that IG and IP administered resveratrol efficiently reduces the frequency and severity of DEN/MNU/DHPN-caused TC-related lesions and would be of values in thyroid tumor prevention. MDPI 2018-02-28 /pmc/articles/PMC5872697/ /pubmed/29495605 http://dx.doi.org/10.3390/nu10030279 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zheng, Xu
Jia, Bin
Song, Xue
Kong, Qing-You
Wu, Mo-Li
Qiu, Ze-Wen
Li, Hong
Liu, Jia
Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title_full Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title_fullStr Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title_full_unstemmed Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title_short Preventive Potential of Resveratrol in Carcinogen-Induced Rat Thyroid Tumorigenesis
title_sort preventive potential of resveratrol in carcinogen-induced rat thyroid tumorigenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872697/
https://www.ncbi.nlm.nih.gov/pubmed/29495605
http://dx.doi.org/10.3390/nu10030279
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