Cargando…

Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy...

Descripción completa

Detalles Bibliográficos
Autores principales: Torlinska, Barbara, Bath, Sarah C., Janjua, Aisha, Boelaert, Kristien, Chan, Shiao-Yng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872709/
https://www.ncbi.nlm.nih.gov/pubmed/29494520
http://dx.doi.org/10.3390/nu10030291
_version_ 1783309896291188736
author Torlinska, Barbara
Bath, Sarah C.
Janjua, Aisha
Boelaert, Kristien
Chan, Shiao-Yng
author_facet Torlinska, Barbara
Bath, Sarah C.
Janjua, Aisha
Boelaert, Kristien
Chan, Shiao-Yng
author_sort Torlinska, Barbara
collection PubMed
description Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 µg/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required.
format Online
Article
Text
id pubmed-5872709
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58727092018-03-30 Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC) Torlinska, Barbara Bath, Sarah C. Janjua, Aisha Boelaert, Kristien Chan, Shiao-Yng Nutrients Article Severe iodine deficiency during pregnancy has been associated with pregnancy/neonatal loss, and adverse pregnancy outcomes; however, the impact of mild–to–moderate iodine insufficiency, though prevalent in pregnancy, is not well-documented. We assessed whether mild iodine deficiency during pregnancy was associated with pregnancy/infant loss, or with other adverse pregnancy outcomes. We used samples and data from the Avon Longitudinal Study of Parents and Children (ALSPAC), from 3140 singleton pregnancies and from a further 42 women with pregnancy/infant loss. The group was classified as mildly-to-moderately iodine deficient with a median urinary iodine concentration of 95.3 µg/L (IQR 57.0–153.0; median urinary iodine-to-creatinine ratio (UI/Creat) 124 µg/g, IQR 82–198). The likelihood of pregnancy/infant loss was not different across four UI/Creat groups (<50, 50–149, 150–250, >250 µg/g). The incidence of pre-eclampsia, non-proteinuric gestational hypertension, gestational diabetes, glycosuria, anaemia, post-partum haemorrhage, preterm delivery, mode of delivery, being small for gestational age, and large for gestational age did not differ significantly among UI/Creat groups, nor were there any significant differences in the median UI/Creat. We conclude that maternal iodine status was not associated with adverse pregnancy outcomes in a mildly-to-moderately iodine-deficient pregnant population. However, in view of the low number of women with pregnancy/infant loss in our study, further research is required. MDPI 2018-03-01 /pmc/articles/PMC5872709/ /pubmed/29494520 http://dx.doi.org/10.3390/nu10030291 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Torlinska, Barbara
Bath, Sarah C.
Janjua, Aisha
Boelaert, Kristien
Chan, Shiao-Yng
Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title_full Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title_fullStr Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title_full_unstemmed Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title_short Iodine Status during Pregnancy in a Region of Mild-to-Moderate Iodine Deficiency is not Associated with Adverse Obstetric Outcomes; Results from the Avon Longitudinal Study of Parents and Children (ALSPAC)
title_sort iodine status during pregnancy in a region of mild-to-moderate iodine deficiency is not associated with adverse obstetric outcomes; results from the avon longitudinal study of parents and children (alspac)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872709/
https://www.ncbi.nlm.nih.gov/pubmed/29494520
http://dx.doi.org/10.3390/nu10030291
work_keys_str_mv AT torlinskabarbara iodinestatusduringpregnancyinaregionofmildtomoderateiodinedeficiencyisnotassociatedwithadverseobstetricoutcomesresultsfromtheavonlongitudinalstudyofparentsandchildrenalspac
AT bathsarahc iodinestatusduringpregnancyinaregionofmildtomoderateiodinedeficiencyisnotassociatedwithadverseobstetricoutcomesresultsfromtheavonlongitudinalstudyofparentsandchildrenalspac
AT janjuaaisha iodinestatusduringpregnancyinaregionofmildtomoderateiodinedeficiencyisnotassociatedwithadverseobstetricoutcomesresultsfromtheavonlongitudinalstudyofparentsandchildrenalspac
AT boelaertkristien iodinestatusduringpregnancyinaregionofmildtomoderateiodinedeficiencyisnotassociatedwithadverseobstetricoutcomesresultsfromtheavonlongitudinalstudyofparentsandchildrenalspac
AT chanshiaoyng iodinestatusduringpregnancyinaregionofmildtomoderateiodinedeficiencyisnotassociatedwithadverseobstetricoutcomesresultsfromtheavonlongitudinalstudyofparentsandchildrenalspac