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Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats

Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic ch...

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Autores principales: Ginés, Iris, Gil-Cardoso, Katherine, Serrano, Joan, Casanova-Martí, Àngela, Blay, MTeresa, Pinent, Montserrat, Ardévol, Anna, Terra, Ximena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872733/
https://www.ncbi.nlm.nih.gov/pubmed/29518911
http://dx.doi.org/10.3390/nu10030315
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author Ginés, Iris
Gil-Cardoso, Katherine
Serrano, Joan
Casanova-Martí, Àngela
Blay, MTeresa
Pinent, Montserrat
Ardévol, Anna
Terra, Ximena
author_facet Ginés, Iris
Gil-Cardoso, Katherine
Serrano, Joan
Casanova-Martí, Àngela
Blay, MTeresa
Pinent, Montserrat
Ardévol, Anna
Terra, Ximena
author_sort Ginés, Iris
collection PubMed
description Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10–15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet.
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spelling pubmed-58727332018-03-30 Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats Ginés, Iris Gil-Cardoso, Katherine Serrano, Joan Casanova-Martí, Àngela Blay, MTeresa Pinent, Montserrat Ardévol, Anna Terra, Ximena Nutrients Article Obesity is highly associated with the pathologies included in the concept of the Metabolic Syndrome. Grape-seed proanthocyanins (GSPE) have showed very positive effects against all these metabolic disruptions; however, there is, as yet, no consensus about their effectiveness against an obesogenic challenge, such as a cafeteria diet. We determined the effectiveness of a dose of 500 mg GSPE/kg b.w. (body weight) against the obesogenic effects of a 17-week cafeteria diet, administered as a sub-chronic treatment, 10–15 days before, intermittently and at the end of the diet, in Wistar rats. Body weight, adiposity, indirect calorimetry and plasma parameters were analyzed. GSPE pre-treatment showed a long-lasting effect on body weight and adiposity that was maintained for seven weeks after the last dose. A corrective treatment was administered for the last two weeks of the cafeteria diet intervention; however, it did not effectively correct any of the parameters assessed. The most effective treatment was an intermittent GSPE dosage, administered every second week during the cafeteria diet. This limited body weight gain, adiposity and most lipotoxic effects. Our results support the administration of this GSPE dose, keeping an intermittent interval between dosages longer than every second week, to improve obesogenic disruptions produced by a cafeteria diet. MDPI 2018-03-07 /pmc/articles/PMC5872733/ /pubmed/29518911 http://dx.doi.org/10.3390/nu10030315 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ginés, Iris
Gil-Cardoso, Katherine
Serrano, Joan
Casanova-Martí, Àngela
Blay, MTeresa
Pinent, Montserrat
Ardévol, Anna
Terra, Ximena
Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title_full Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title_fullStr Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title_full_unstemmed Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title_short Effects of an Intermittent Grape-Seed Proanthocyanidin (GSPE) Treatment on a Cafeteria Diet Obesogenic Challenge in Rats
title_sort effects of an intermittent grape-seed proanthocyanidin (gspe) treatment on a cafeteria diet obesogenic challenge in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872733/
https://www.ncbi.nlm.nih.gov/pubmed/29518911
http://dx.doi.org/10.3390/nu10030315
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