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Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study

Nutritional supplements are popular among athletes to improve performance and physical recovery. Protein supplements fulfill this function by improving performance and increasing muscle mass; however, their effect on other organs or systems is less well known. Diet alterations can induce gut microbi...

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Autores principales: Moreno-Pérez, Diego, Bressa, Carlo, Bailén, María, Hamed-Bousdar, Safa, Naclerio, Fernando, Carmona, Manuel, Pérez, Margarita, González-Soltero, Rocío, Montalvo-Lominchar, Maria Gregoria, Carabaña, Claudia, Larrosa, Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872755/
https://www.ncbi.nlm.nih.gov/pubmed/29534465
http://dx.doi.org/10.3390/nu10030337
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author Moreno-Pérez, Diego
Bressa, Carlo
Bailén, María
Hamed-Bousdar, Safa
Naclerio, Fernando
Carmona, Manuel
Pérez, Margarita
González-Soltero, Rocío
Montalvo-Lominchar, Maria Gregoria
Carabaña, Claudia
Larrosa, Mar
author_facet Moreno-Pérez, Diego
Bressa, Carlo
Bailén, María
Hamed-Bousdar, Safa
Naclerio, Fernando
Carmona, Manuel
Pérez, Margarita
González-Soltero, Rocío
Montalvo-Lominchar, Maria Gregoria
Carabaña, Claudia
Larrosa, Mar
author_sort Moreno-Pérez, Diego
collection PubMed
description Nutritional supplements are popular among athletes to improve performance and physical recovery. Protein supplements fulfill this function by improving performance and increasing muscle mass; however, their effect on other organs or systems is less well known. Diet alterations can induce gut microbiota imbalance, with beneficial or deleterious consequences for the host. To test this, we performed a randomized pilot study in cross-country runners whose diets were complemented with a protein supplement (whey isolate and beef hydrolysate) (n = 12) or maltodextrin (control) (n = 12) for 10 weeks. Microbiota, water content, pH, ammonia, and short-chain fatty acids (SCFAs) were analyzed in fecal samples, whereas malondialdehyde levels (oxidative stress marker) were determined in plasma and urine. Fecal pH, water content, ammonia, and SCFA concentrations did not change, indicating that protein supplementation did not increase the presence of these fermentation-derived metabolites. Similarly, it had no impact on plasma or urine malondialdehyde levels; however, it increased the abundance of the Bacteroidetes phylum and decreased the presence of health-related taxa including Roseburia, Blautia, and Bifidobacterium longum. Thus, long-term protein supplementation may have a negative impact on gut microbiota. Further research is needed to establish the impact of protein supplements on gut microbiota.
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spelling pubmed-58727552018-03-30 Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study Moreno-Pérez, Diego Bressa, Carlo Bailén, María Hamed-Bousdar, Safa Naclerio, Fernando Carmona, Manuel Pérez, Margarita González-Soltero, Rocío Montalvo-Lominchar, Maria Gregoria Carabaña, Claudia Larrosa, Mar Nutrients Article Nutritional supplements are popular among athletes to improve performance and physical recovery. Protein supplements fulfill this function by improving performance and increasing muscle mass; however, their effect on other organs or systems is less well known. Diet alterations can induce gut microbiota imbalance, with beneficial or deleterious consequences for the host. To test this, we performed a randomized pilot study in cross-country runners whose diets were complemented with a protein supplement (whey isolate and beef hydrolysate) (n = 12) or maltodextrin (control) (n = 12) for 10 weeks. Microbiota, water content, pH, ammonia, and short-chain fatty acids (SCFAs) were analyzed in fecal samples, whereas malondialdehyde levels (oxidative stress marker) were determined in plasma and urine. Fecal pH, water content, ammonia, and SCFA concentrations did not change, indicating that protein supplementation did not increase the presence of these fermentation-derived metabolites. Similarly, it had no impact on plasma or urine malondialdehyde levels; however, it increased the abundance of the Bacteroidetes phylum and decreased the presence of health-related taxa including Roseburia, Blautia, and Bifidobacterium longum. Thus, long-term protein supplementation may have a negative impact on gut microbiota. Further research is needed to establish the impact of protein supplements on gut microbiota. MDPI 2018-03-10 /pmc/articles/PMC5872755/ /pubmed/29534465 http://dx.doi.org/10.3390/nu10030337 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moreno-Pérez, Diego
Bressa, Carlo
Bailén, María
Hamed-Bousdar, Safa
Naclerio, Fernando
Carmona, Manuel
Pérez, Margarita
González-Soltero, Rocío
Montalvo-Lominchar, Maria Gregoria
Carabaña, Claudia
Larrosa, Mar
Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title_full Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title_fullStr Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title_full_unstemmed Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title_short Effect of a Protein Supplement on the Gut Microbiota of Endurance Athletes: A Randomized, Controlled, Double-Blind Pilot Study
title_sort effect of a protein supplement on the gut microbiota of endurance athletes: a randomized, controlled, double-blind pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872755/
https://www.ncbi.nlm.nih.gov/pubmed/29534465
http://dx.doi.org/10.3390/nu10030337
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