Retinal Cell Type DNA Methylation and Histone Modifications Predict Reprogramming Efficiency and Retinogenesis in 3D Organoid Cultures

Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifications (epigenetic memory), of their cellular origins, an...

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Detalles Bibliográficos
Autores principales: Wang, Lu, Hiler, Daniel, Xu, Beisi, AlDiri, Issam, Chen, Xiang, Zhou, Xin, Griffiths, Lyra, Valentine, Marc, Shirinifard, Abbas, Sablauer, András, Thiagarajan, Suresh, Barabas, Marie-Elizabeth, Zhang, Jiakun, Johnson, Dianna, Frase, Sharon, Dyer, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872828/
https://www.ncbi.nlm.nih.gov/pubmed/29514090
http://dx.doi.org/10.1016/j.celrep.2018.01.075

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