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Postoperative Cardiac Surgery Outcomes in a Statin-Native Population

BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: W...

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Autores principales: Aboulnaga, Sameh, Mahfouz, Ahmed, Ewila, Hesham A., Tuli, Alejandro Kohn, Singh, Rajvir, Omar, Amr S., Al Khualifi, Abdulaziz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872868/
https://www.ncbi.nlm.nih.gov/pubmed/29628586
http://dx.doi.org/10.4103/aer.AER_229_17
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author Aboulnaga, Sameh
Mahfouz, Ahmed
Ewila, Hesham A.
Tuli, Alejandro Kohn
Singh, Rajvir
Omar, Amr S.
Al Khualifi, Abdulaziz
author_facet Aboulnaga, Sameh
Mahfouz, Ahmed
Ewila, Hesham A.
Tuli, Alejandro Kohn
Singh, Rajvir
Omar, Amr S.
Al Khualifi, Abdulaziz
author_sort Aboulnaga, Sameh
collection PubMed
description BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. PATIENTS: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery. INTERVENTION: Patients were divided into two groups; Group I – statin users and Group II – nonusers. MEASUREMENTS: Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries. RESULTS: The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group (P = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital (P = 0.036, 0.04, and 0.027, respectively). CONCLUSIONS: Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events.
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spelling pubmed-58728682018-04-06 Postoperative Cardiac Surgery Outcomes in a Statin-Native Population Aboulnaga, Sameh Mahfouz, Ahmed Ewila, Hesham A. Tuli, Alejandro Kohn Singh, Rajvir Omar, Amr S. Al Khualifi, Abdulaziz Anesth Essays Res Original Article BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. PATIENTS: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery. INTERVENTION: Patients were divided into two groups; Group I – statin users and Group II – nonusers. MEASUREMENTS: Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries. RESULTS: The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group (P = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital (P = 0.036, 0.04, and 0.027, respectively). CONCLUSIONS: Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5872868/ /pubmed/29628586 http://dx.doi.org/10.4103/aer.AER_229_17 Text en Copyright: 2018 © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Aboulnaga, Sameh
Mahfouz, Ahmed
Ewila, Hesham A.
Tuli, Alejandro Kohn
Singh, Rajvir
Omar, Amr S.
Al Khualifi, Abdulaziz
Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title_full Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title_fullStr Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title_full_unstemmed Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title_short Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
title_sort postoperative cardiac surgery outcomes in a statin-native population
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872868/
https://www.ncbi.nlm.nih.gov/pubmed/29628586
http://dx.doi.org/10.4103/aer.AER_229_17
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