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Postoperative Cardiac Surgery Outcomes in a Statin-Native Population
BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: W...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872868/ https://www.ncbi.nlm.nih.gov/pubmed/29628586 http://dx.doi.org/10.4103/aer.AER_229_17 |
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author | Aboulnaga, Sameh Mahfouz, Ahmed Ewila, Hesham A. Tuli, Alejandro Kohn Singh, Rajvir Omar, Amr S. Al Khualifi, Abdulaziz |
author_facet | Aboulnaga, Sameh Mahfouz, Ahmed Ewila, Hesham A. Tuli, Alejandro Kohn Singh, Rajvir Omar, Amr S. Al Khualifi, Abdulaziz |
author_sort | Aboulnaga, Sameh |
collection | PubMed |
description | BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. PATIENTS: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery. INTERVENTION: Patients were divided into two groups; Group I – statin users and Group II – nonusers. MEASUREMENTS: Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries. RESULTS: The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group (P = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital (P = 0.036, 0.04, and 0.027, respectively). CONCLUSIONS: Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events. |
format | Online Article Text |
id | pubmed-5872868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58728682018-04-06 Postoperative Cardiac Surgery Outcomes in a Statin-Native Population Aboulnaga, Sameh Mahfouz, Ahmed Ewila, Hesham A. Tuli, Alejandro Kohn Singh, Rajvir Omar, Amr S. Al Khualifi, Abdulaziz Anesth Essays Res Original Article BACKGROUND: Statin utilization had been associated with improved survival after cardiac surgery. We aim to study whether perioperative treatment with statin could be associated with increased postoperative complications. DESIGN: This was a retrospective, descriptive, single-center study. SETTINGS: We analyzed morbidity after cardiac surgery as well as the outcome related to statin therapy in a tertiary cardiac center. PATIENTS: A total of 202 consecutive patients were enrolled over 1 year after cardiac surgery. INTERVENTION: Patients were divided into two groups; Group I – statin users and Group II – nonusers. MEASUREMENTS: Measurements were baseline and follow-up laboratory markers for muscular injury including cardiac muscle and hepatic injuries and renal injuries. RESULTS: The incidence of rhabdomyolysis and elevation of liver enzymes did not differ between both groups. Postoperative atrial fibrillation was significantly lower in the statin group (P = 0.02). In addition, peak cardiac troponin and creatine kinase-MB did not differ significantly in the statin group. Statin-treated group had significant lower length of mechanical ventilation, and length of stay in the Intensive Care Unit and hospital (P = 0.036, 0.04, and 0.027, respectively). CONCLUSIONS: Therapy with statin before cardiac surgeries was not associated with high incidence of adverse events. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5872868/ /pubmed/29628586 http://dx.doi.org/10.4103/aer.AER_229_17 Text en Copyright: 2018 © Anesthesia: Essays and Researches http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Aboulnaga, Sameh Mahfouz, Ahmed Ewila, Hesham A. Tuli, Alejandro Kohn Singh, Rajvir Omar, Amr S. Al Khualifi, Abdulaziz Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title | Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title_full | Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title_fullStr | Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title_full_unstemmed | Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title_short | Postoperative Cardiac Surgery Outcomes in a Statin-Native Population |
title_sort | postoperative cardiac surgery outcomes in a statin-native population |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872868/ https://www.ncbi.nlm.nih.gov/pubmed/29628586 http://dx.doi.org/10.4103/aer.AER_229_17 |
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