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MAPK Phosphatase-1 Deficiency Exacerbates the Severity of Imiquimod-Induced Psoriasiform Skin Disease
Persistent activation of mitogen-activated protein kinase (MAPK) is believed to be involved in psoriasis pathogenesis. MAPK phosphatase-1 (MKP-1) is an important negative regulator of MAPK activity, but the cellular and molecular mechanisms of MKP-1 in psoriasis development are largely unknown. In t...
Autores principales: | Zhao, Weiheng, Xiao, Shuxiu, Li, Hongjin, Zheng, Tingting, Huang, Jian, Hu, Ran, Zhang, Baohua, Liu, Xinguang, Huang, Gonghua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873221/ https://www.ncbi.nlm.nih.gov/pubmed/29619028 http://dx.doi.org/10.3389/fimmu.2018.00569 |
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