Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology

It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. We show that h...

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Detalles Bibliográficos
Autores principales: Abrusán, György, Marsh, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873459/
https://www.ncbi.nlm.nih.gov/pubmed/29562182
http://dx.doi.org/10.1016/j.celrep.2018.02.085

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873459/
https://www.ncbi.nlm.nih.gov/pubmed/29562182
http://dx.doi.org/10.1016/j.celrep.2018.02.085

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