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Ligand Binding Site Structure Influences the Evolution of Protein Complex Function and Topology
It has been suggested that the evolution of protein complexes is significantly influenced by stochastic, non-adaptive processes. Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes. We show that h...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873459/ https://www.ncbi.nlm.nih.gov/pubmed/29562182 http://dx.doi.org/10.1016/j.celrep.2018.02.085 |