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Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus
Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. We use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals chronically infected with HCV, pre...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873514/ https://www.ncbi.nlm.nih.gov/pubmed/28394351 http://dx.doi.org/10.1038/ng.3835 |
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| author | Ansari, M. Azim Pedergnana, Vincent Ip, Camilla Magri, Andrea Von Delft, Annette Bonsall, David Chaturvedi, Nimisha Bartha, Istvan Smith, David Nicholson, George McVean, Gilean Trebes, Amy Piazza, Paolo Fellay, Jacques Cooke, Graham Foster, Graham R Hudson, Emma McLauchlan, John Simmonds, Peter Bowden, Rory Klenerman, Paul Barnes, Eleanor Spencer, Chris C. A. |
| author_facet | Ansari, M. Azim Pedergnana, Vincent Ip, Camilla Magri, Andrea Von Delft, Annette Bonsall, David Chaturvedi, Nimisha Bartha, Istvan Smith, David Nicholson, George McVean, Gilean Trebes, Amy Piazza, Paolo Fellay, Jacques Cooke, Graham Foster, Graham R Hudson, Emma McLauchlan, John Simmonds, Peter Bowden, Rory Klenerman, Paul Barnes, Eleanor Spencer, Chris C. A. |
| author_sort | Ansari, M. Azim |
| collection | PubMed |
| description | Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. We use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals chronically infected with HCV, predominately genotype 3. We show that both HLA alleles and interferon lambda innate immune system genes drive viral genome polymorphism, and that IFNL4 genotypes determine HCV viral load through a mechanism that is dependent on a specific polymorphism in the HCV polyprotein. We highlight the interplay between innate immune responses and the viral genome in HCV control. |
| format | Online Article Text |
| id | pubmed-5873514 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58735142018-03-28 Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus Ansari, M. Azim Pedergnana, Vincent Ip, Camilla Magri, Andrea Von Delft, Annette Bonsall, David Chaturvedi, Nimisha Bartha, Istvan Smith, David Nicholson, George McVean, Gilean Trebes, Amy Piazza, Paolo Fellay, Jacques Cooke, Graham Foster, Graham R Hudson, Emma McLauchlan, John Simmonds, Peter Bowden, Rory Klenerman, Paul Barnes, Eleanor Spencer, Chris C. A. Nat Genet Article Outcomes of hepatitis C virus (HCV) infection and treatment depend on viral and host genetic factors. We use human genome-wide genotyping arrays and new whole-genome HCV viral sequencing technologies to perform a systematic genome-to-genome study of 542 individuals chronically infected with HCV, predominately genotype 3. We show that both HLA alleles and interferon lambda innate immune system genes drive viral genome polymorphism, and that IFNL4 genotypes determine HCV viral load through a mechanism that is dependent on a specific polymorphism in the HCV polyprotein. We highlight the interplay between innate immune responses and the viral genome in HCV control. 2017-04-10 2017-05 /pmc/articles/PMC5873514/ /pubmed/28394351 http://dx.doi.org/10.1038/ng.3835 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Ansari, M. Azim Pedergnana, Vincent Ip, Camilla Magri, Andrea Von Delft, Annette Bonsall, David Chaturvedi, Nimisha Bartha, Istvan Smith, David Nicholson, George McVean, Gilean Trebes, Amy Piazza, Paolo Fellay, Jacques Cooke, Graham Foster, Graham R Hudson, Emma McLauchlan, John Simmonds, Peter Bowden, Rory Klenerman, Paul Barnes, Eleanor Spencer, Chris C. A. Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title | Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title_full | Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title_fullStr | Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title_full_unstemmed | Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title_short | Genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis C virus |
| title_sort | genome-to-genome analysis highlights the impact of the human innate and adaptive immune systems on the hepatitis c virus |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873514/ https://www.ncbi.nlm.nih.gov/pubmed/28394351 http://dx.doi.org/10.1038/ng.3835 |
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