KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer

Triple-negative breast cancers (TNBCs) display a complex spectrum of mutations and chromosomal aberrations. Chromosome 5q (5q) loss is detected in up to 70% of TNBCs, but little is known regarding the genetic drivers associated with this event. Here, we show somatic deletion of a region syntenic wit...

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Detalles Bibliográficos
Autores principales: Knight, Jennifer F., Sung, Vanessa Y.C., Kuzmin, Elena, Couzens, Amber L., de Verteuil, Danielle A., Ratcliffe, Colin D.H., Coelho, Paula P., Johnson, Radia M., Samavarchi-Tehrani, Payman, Gruosso, Tina, Smith, Harvey W., Lee, Wontae, Saleh, Sadiq M., Zuo, Dongmei, Zhao, Hong, Guiot, Marie-Christine, Davis, Ryan R., Gregg, Jeffrey P., Moraes, Christopher, Gingras, Anne-Claude, Park, Morag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873529/
https://www.ncbi.nlm.nih.gov/pubmed/29562176
http://dx.doi.org/10.1016/j.celrep.2018.02.095

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