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Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems

OBJECTIVE: To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes....

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Autores principales: Passaroni, Andréia Cristina, Felicio, Marcello Laneza, de Campos, Nelson Leonardo Kerdahi Leite, Silva, Marcos Augusto de Moraes, Yoshida, Winston Bonida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Cirurgia Cardiovascular 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873773/
https://www.ncbi.nlm.nih.gov/pubmed/29617504
http://dx.doi.org/10.21470/1678-9741-2017-0125
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author Passaroni, Andréia Cristina
Felicio, Marcello Laneza
de Campos, Nelson Leonardo Kerdahi Leite
Silva, Marcos Augusto de Moraes
Yoshida, Winston Bonida
author_facet Passaroni, Andréia Cristina
Felicio, Marcello Laneza
de Campos, Nelson Leonardo Kerdahi Leite
Silva, Marcos Augusto de Moraes
Yoshida, Winston Bonida
author_sort Passaroni, Andréia Cristina
collection PubMed
description OBJECTIVE: To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. METHODS: This was a prospective, randomized trial of 60 patients assigned to either roller pump (G1, n=30) or centrifugal pump (G2, n=30) bypass. Markers of hemolysis (serum haptoglobin, lactate dehydrogenase [LDH]) and inflammation (interleukin [IL]1ß, IL-6, and TNF-α) were measured and analyzed. RESULTS: There was no significant between-group difference in the variables of interest. In G1, there was a positive association with IL-6 and TNF-α (P<0.01 and P<0.05, respectively). In G2, there was a positive association with LDH in the postoperative period (P<0.5). At 24h post-cardiopulmonary bypass, there were positive associations between LDH and IL-1ß (P<0.05), LDH and TNF-α (P<0.01), haptoglobin and TNF-α (P<0.05), and LDH and TNF-α (P<0.01) in G1, and between LDH and IL-6 (P<0.01), LDH and TNF-α (P<0.01), and LDH and IL-6 (P<0.01) in G2. CONCLUSION: There were no significant between-group differences in markers of hemolysis or inflammation. IL-6 and TNF-α were positively associated with duration of cardiopulmonary bypass in G1, while LDH was positively associated with duration of cardiopulmonary bypass in G2. The rate of significant associations between markers of hemolysis and inflammation was higher in the roller pump group (G1). REGISTRATION NUMBER: ReBEC (RBR-92b9dg).
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spelling pubmed-58737732018-04-02 Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems Passaroni, Andréia Cristina Felicio, Marcello Laneza de Campos, Nelson Leonardo Kerdahi Leite Silva, Marcos Augusto de Moraes Yoshida, Winston Bonida Braz J Cardiovasc Surg Original Article OBJECTIVE: To compare the perioperative incidence rates of hemolysis and inflammatory response in patients undergoing coronary artery bypass grafting with the two main types of cardiopulmonary bypass, centrifugal and roller pumps, and establish correlations among hemolytic and inflammatory changes. METHODS: This was a prospective, randomized trial of 60 patients assigned to either roller pump (G1, n=30) or centrifugal pump (G2, n=30) bypass. Markers of hemolysis (serum haptoglobin, lactate dehydrogenase [LDH]) and inflammation (interleukin [IL]1ß, IL-6, and TNF-α) were measured and analyzed. RESULTS: There was no significant between-group difference in the variables of interest. In G1, there was a positive association with IL-6 and TNF-α (P<0.01 and P<0.05, respectively). In G2, there was a positive association with LDH in the postoperative period (P<0.5). At 24h post-cardiopulmonary bypass, there were positive associations between LDH and IL-1ß (P<0.05), LDH and TNF-α (P<0.01), haptoglobin and TNF-α (P<0.05), and LDH and TNF-α (P<0.01) in G1, and between LDH and IL-6 (P<0.01), LDH and TNF-α (P<0.01), and LDH and IL-6 (P<0.01) in G2. CONCLUSION: There were no significant between-group differences in markers of hemolysis or inflammation. IL-6 and TNF-α were positively associated with duration of cardiopulmonary bypass in G1, while LDH was positively associated with duration of cardiopulmonary bypass in G2. The rate of significant associations between markers of hemolysis and inflammation was higher in the roller pump group (G1). REGISTRATION NUMBER: ReBEC (RBR-92b9dg). Sociedade Brasileira de Cirurgia Cardiovascular 2018 /pmc/articles/PMC5873773/ /pubmed/29617504 http://dx.doi.org/10.21470/1678-9741-2017-0125 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Passaroni, Andréia Cristina
Felicio, Marcello Laneza
de Campos, Nelson Leonardo Kerdahi Leite
Silva, Marcos Augusto de Moraes
Yoshida, Winston Bonida
Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title_full Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title_fullStr Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title_full_unstemmed Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title_short Hemolysis and Inflammatory Response to Extracorporeal Circulation during On-Pump CABG: Comparison between Roller and Centrifugal Pump Systems
title_sort hemolysis and inflammatory response to extracorporeal circulation during on-pump cabg: comparison between roller and centrifugal pump systems
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873773/
https://www.ncbi.nlm.nih.gov/pubmed/29617504
http://dx.doi.org/10.21470/1678-9741-2017-0125
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