Cargando…

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

Polypeptide vaccines effectively activate human T cells but suffer from poor biological stability, which confines both transport logistics and in vivo therapeutic activity. Synthetic biology has the potential to address these limitations through the generation of highly stable antigenic “mimics” usi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miles, John J., Tan, Mai Ping, Dolton, Garry, Edwards, Emily S.J., Galloway, Sarah A.E., Laugel, Bruno, Clement, Mathew, Makinde, Julia, Ladell, Kristin, Matthews, Katherine K., Watkins, Thomas S., Tungatt, Katie, Wong, Yide, Lee, Han Siean, Clark, Richard J., Pentier, Johanne M., Attaf, Meriem, Lissina, Anya, Ager, Ann, Gallimore, Awen, Rizkallah, Pierre J., Gras, Stephanie, Rossjohn, Jamie, Burrows, Scott R., Cole, David K., Price, David A., Sewell, Andrew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873848/ https://www.ncbi.nlm.nih.gov/pubmed/29528337 http://dx.doi.org/10.1172/JCI91512

Ejemplares similares

Comparison of peptide–major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells
por: Dolton, G, et al.
Publicado: (2014)

T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting
por: Ekeruche-Makinde, Julia, et al.
Publicado: (2012)

A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
por: Bianchi, Valentina, et al.
Publicado: (2016)

Advances in T-Cell Epitope Engineering
por: Pentier, Johanne M., et al.
Publicado: (2013)

Induction of influenza-specific local CD8 T-cells in the respiratory tract after aerosol delivery of vaccine antigen or virus in the Babraham inbred pig
por: Tungatt, Katie, et al.
Publicado: (2018)

An Engineered Synthetic Pathway for Discovering Nonnatural Nonribosomal Peptides in Escherichia coli
por: Cleto, Sara, et al.
Publicado: (2017)

High endothelial venules: Help or hindrance in the quest for antitumor immunity?
por: Gallimore, Awen, et al.
Publicado: (2013)

Human leukocyte antigen (HLA) class II peptide flanking residues tune the immunogenicity of a human tumor-derived epitope
por: MacLachlan, Bruce J., et al.
Publicado: (2019)

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations
por: Rius, Cristina, et al.
Publicado: (2018)

A phosphite-based screening platform for identification of enzymes favoring nonnatural cofactors
por: Liu, Yuxue, et al.
Publicado: (2022)

Genome-wide CRISPR-Cas9 Screening Reveals Ubiquitous T cell Cancer Targeting via the monomorphic MHC class I related protein MR1
por: Crowther, Michael D., et al.
Publicado: (2020)

Peptide Super-Agonist Enhances T-Cell Responses to Melanoma
por: Galloway, Sarah A. E., et al.
Publicado: (2019)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors
por: Szomolay, Barbara, et al.
Publicado: (2016)

αβ T cell receptors as predictors of health and disease
por: Attaf, Meriem, et al.
Publicado: (2015)

CD4(+) T Cells Recognize Conserved Influenza A Epitopes through Shared Patterns of V-Gene Usage and Complementary Biochemical Features
por: Greenshields-Watson, Alexander, et al.
Publicado: (2020)

Tertiary Lymphoid Structures in Cancer: Drivers of Antitumor Immunity, Immunosuppression, or Bystander Sentinels in Disease?
por: Colbeck, Emily Jayne, et al.
Publicado: (2017)

Structural Mechanism Underpinning Cross-reactivity of a CD8(+) T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
por: Cole, David K., et al.
Publicado: (2017)

Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards
por: Kunkel, Marius, et al.
Publicado: (2018)

Progression of carcinogen‐induced fibrosarcomas is associated with the accumulation of naïve CD4+ T cells via blood vessels and lymphatics
por: Ondondo, Beatrice, et al.
Publicado: (2013)

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Corrigendum: Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life
por: Attaf, Meriem, et al.
Publicado: (2020)

Nonnatural amino acid incorporation into the methionine 214 position of the metzincin Pseudomonas aeruginosa alkaline protease
por: Walasek, Paula, et al.
Publicado: (2005)

Potent T cell agonism mediated by a very rapid TCR/pMHC interaction
por: Boulter, Jonathan M, et al.
Publicado: (2007)

Naive CD8(+) T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics
por: Neller, Michelle A, et al.
Publicado: (2015)

Modification of the carboxy-terminal flanking region of a universal influenza epitope alters CD4(+) T-cell repertoire selection
por: Cole, David K., et al.
Publicado: (2012)

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells
por: Laugel, Bruno, et al.
Publicado: (2016)

Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer
por: Singh, Raman Deep, et al.
Publicado: (2007)

Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
por: Cole, David K., et al.
Publicado: (2016)

Four-base codon mediated mRNA display to construct peptide libraries that contain multiple nonnatural amino acids
por: Muranaka, Norihito, et al.
Publicado: (2006)

High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression
por: Bento, Diana Costa, et al.
Publicado: (2015)

Hunting for clues: Regulatory T cells and colorectal cancer
por: Gallimore, Awen, et al.
Publicado: (2012)

The link between T cell activation and development of functionally useful tumour-associated high endothelial venules
por: Milutinovic, Stefan, et al.
Publicado: (2023)

Optimized Peptide–MHC Multimer Protocols for Detection and Isolation of Autoimmune T-Cells
por: Dolton, Garry, et al.
Publicado: (2018)

Enhanced Detection of Antigen-Specific CD4(+) T Cells Using Altered Peptide Flanking Residue Peptide–MHC Class II Multimers
por: Holland, Christopher J., et al.
Publicado: (2015)

Application of magnetic field hyperthermia and superparamagnetic iron oxide nanoparticles to HIV-1-specific T-cell cytotoxicity
por: Williams, James P, et al.
Publicado: (2013)

Functional and biophysical characterization of an HLA-A*6801-restricted HIV-specific T cell receptor
por: Gostick, Emma, et al.
Publicado: (2007)

Reversible Oligonucleotide Chain Blocking Enables Bead Capture and Amplification of T-Cell Receptor α and β Chain mRNAs
por: Hanson, W. Miachel, et al.
Publicado: (2016)

Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection
por: Miles, John J., et al.
Publicado: (2010)

Genetically engineered biosynthetic pathways for nonnatural C(60) carotenoids using C(5)-elongases and C(50)-cyclases in Escherichia coli
por: Li, Ling, et al.
Publicado: (2019)

Tracking the kinetics of intrahepatic immune responses by repeated fine needle aspiration of the liver
por: Pembroke, Tom, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g3e2g3roqicrcbsvnp0lqpfcvr