N-terminal Sumoylation of Centromeric Histone H3 Variant Cse4 Regulates Its Proteolysis To Prevent Mislocalization to Non-centromeric Chromatin

Stringent regulation of cellular levels of evolutionarily conserved centromeric histone H3 variant (CENP-A in humans, CID in flies, Cse4 in yeast) prevents its mislocalization to non-centromeric chromatin. Overexpression and mislocalization of CENP-A has been observed in cancers and leads to aneuplo...

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Detalles Bibliográficos
Autores principales: Ohkuni, Kentaro, Levy-Myers, Reuben, Warren, Jack, Au, Wei-Chun, Takahashi, Yoshimitsu, Baker, Richard E., Basrai, Munira A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2018
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873912/
https://www.ncbi.nlm.nih.gov/pubmed/29432128
http://dx.doi.org/10.1534/g3.117.300419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873912/
https://www.ncbi.nlm.nih.gov/pubmed/29432128
http://dx.doi.org/10.1534/g3.117.300419

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