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Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model

Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well...

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Autores principales: Williams, Geraint P., Wu, Benjamin, Liu, Yu Chi, Teo, Ericia, Nyein, Chan L., Peh, Gary, Tan, Donald T., Mehta, Jodhbir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874005/
https://www.ncbi.nlm.nih.gov/pubmed/29590157
http://dx.doi.org/10.1371/journal.pone.0194209
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author Williams, Geraint P.
Wu, Benjamin
Liu, Yu Chi
Teo, Ericia
Nyein, Chan L.
Peh, Gary
Tan, Donald T.
Mehta, Jodhbir S.
author_facet Williams, Geraint P.
Wu, Benjamin
Liu, Yu Chi
Teo, Ericia
Nyein, Chan L.
Peh, Gary
Tan, Donald T.
Mehta, Jodhbir S.
author_sort Williams, Geraint P.
collection PubMed
description Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27μm LASIK, -45 ± 18μm SMILE and 28 ± 17μm Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted.
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spelling pubmed-58740052018-04-06 Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model Williams, Geraint P. Wu, Benjamin Liu, Yu Chi Teo, Ericia Nyein, Chan L. Peh, Gary Tan, Donald T. Mehta, Jodhbir S. PLoS One Research Article Hyperopia is a common refractive error, apparent in 25% of Europeans. Treatments include spectacles, contact lenses, laser interventions and surgery including implantable contact lenses and lens extraction. Laser treatment offers an expedient and reliable means of correcting ametropia. LASIK is well-established however SMILE (small-incision lenticule extraction) or lenticule implantation (derived from myopic laser-correction) are newer options. In this study we compared the outcomes of hyperopic LASIK, SMILE and lenticule re-implantation in a primate model at +2D/+4D treatment. While re-implantation showed the greatest regression, broadly comparable refractive results were seen at 3-months with SMILE and LASIK (<1.4D of intended), but a greater tendency to regression in +2D lenticule reimplantation. Central corneal thickness showed greater variation at +2D treatment, but central thickening during lenticule reimplantation at +4D treatment was seen (-17± 27μm LASIK, -45 ± 18μm SMILE and 28 ± 17μm Re-implantation; p <0.01) with expected paracentral thinning following SMILE. Although in vivo confocal microscopy appeared to show higher reflectivity in all +4D treatment groups, there were minimal and inconsistent changes in inflammatory responses between modalities. SMILE and lenticule re-implantation may represent a safe and viable method for treating hyperopia, but further optimization for lower hyperopic treatments is warranted. Public Library of Science 2018-03-28 /pmc/articles/PMC5874005/ /pubmed/29590157 http://dx.doi.org/10.1371/journal.pone.0194209 Text en © 2018 Williams et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Williams, Geraint P.
Wu, Benjamin
Liu, Yu Chi
Teo, Ericia
Nyein, Chan L.
Peh, Gary
Tan, Donald T.
Mehta, Jodhbir S.
Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title_full Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title_fullStr Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title_full_unstemmed Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title_short Hyperopic refractive correction by LASIK, SMILE or lenticule reimplantation in a non-human primate model
title_sort hyperopic refractive correction by lasik, smile or lenticule reimplantation in a non-human primate model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874005/
https://www.ncbi.nlm.nih.gov/pubmed/29590157
http://dx.doi.org/10.1371/journal.pone.0194209
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