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Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies

Conflicting results identifying the association between tooth loss and cardiovascular disease and stroke have been reported. Therefore, a dose-response meta-analysis was performed to clarify and quantitatively assess the correlation between tooth loss and cardiovascular disease and stroke risk. Up t...

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Autores principales: Cheng, Fei, Zhang, Mi, Wang, Quan, Xu, Haijun, Dong, Xiao, Gao, Zhen, Chen, Jiajuan, Wei, Yunjie, Qin, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874035/
https://www.ncbi.nlm.nih.gov/pubmed/29590166
http://dx.doi.org/10.1371/journal.pone.0194563
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author Cheng, Fei
Zhang, Mi
Wang, Quan
Xu, Haijun
Dong, Xiao
Gao, Zhen
Chen, Jiajuan
Wei, Yunjie
Qin, Fen
author_facet Cheng, Fei
Zhang, Mi
Wang, Quan
Xu, Haijun
Dong, Xiao
Gao, Zhen
Chen, Jiajuan
Wei, Yunjie
Qin, Fen
author_sort Cheng, Fei
collection PubMed
description Conflicting results identifying the association between tooth loss and cardiovascular disease and stroke have been reported. Therefore, a dose-response meta-analysis was performed to clarify and quantitatively assess the correlation between tooth loss and cardiovascular disease and stroke risk. Up to March 2017, seventeen cohort studies were included in current meta-analysis, involving a total of 879084 participants with 43750 incident cases. Our results showed statistically significant increment association between tooth loss and cardiovascular disease and stroke risk. Subgroups analysis indicated that tooth loss was associated with a significant risk of cardiovascular disease and stroke in Asia and Caucasian. Furthermore, tooth loss was associated with a significant risk of cardiovascular disease and stroke in fatal cases and nonfatal cases. Additionally, a significant dose-response relationship was observed between tooth loss and cardiovascular disease and stroke risk. Increasing per 2 of tooth loss was associated with a 3% increment of coronary heart disease risk; increasing per 2 of tooth loss was associated with a 3% increment of stroke risk. Subgroup meta-analyses in study design, study quality, number of participants and number of cases showed consistent findings. No publication bias was observed in this meta-analysis. Considering these promising results, tooth loss might provide harmful health benefits.
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spelling pubmed-58740352018-04-06 Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies Cheng, Fei Zhang, Mi Wang, Quan Xu, Haijun Dong, Xiao Gao, Zhen Chen, Jiajuan Wei, Yunjie Qin, Fen PLoS One Research Article Conflicting results identifying the association between tooth loss and cardiovascular disease and stroke have been reported. Therefore, a dose-response meta-analysis was performed to clarify and quantitatively assess the correlation between tooth loss and cardiovascular disease and stroke risk. Up to March 2017, seventeen cohort studies were included in current meta-analysis, involving a total of 879084 participants with 43750 incident cases. Our results showed statistically significant increment association between tooth loss and cardiovascular disease and stroke risk. Subgroups analysis indicated that tooth loss was associated with a significant risk of cardiovascular disease and stroke in Asia and Caucasian. Furthermore, tooth loss was associated with a significant risk of cardiovascular disease and stroke in fatal cases and nonfatal cases. Additionally, a significant dose-response relationship was observed between tooth loss and cardiovascular disease and stroke risk. Increasing per 2 of tooth loss was associated with a 3% increment of coronary heart disease risk; increasing per 2 of tooth loss was associated with a 3% increment of stroke risk. Subgroup meta-analyses in study design, study quality, number of participants and number of cases showed consistent findings. No publication bias was observed in this meta-analysis. Considering these promising results, tooth loss might provide harmful health benefits. Public Library of Science 2018-03-28 /pmc/articles/PMC5874035/ /pubmed/29590166 http://dx.doi.org/10.1371/journal.pone.0194563 Text en © 2018 Cheng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Cheng, Fei
Zhang, Mi
Wang, Quan
Xu, Haijun
Dong, Xiao
Gao, Zhen
Chen, Jiajuan
Wei, Yunjie
Qin, Fen
Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title_full Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title_fullStr Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title_full_unstemmed Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title_short Tooth loss and risk of cardiovascular disease and stroke: A dose-response meta analysis of prospective cohort studies
title_sort tooth loss and risk of cardiovascular disease and stroke: a dose-response meta analysis of prospective cohort studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874035/
https://www.ncbi.nlm.nih.gov/pubmed/29590166
http://dx.doi.org/10.1371/journal.pone.0194563
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