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Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study

Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional ma...

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Detalles Bibliográficos
Autores principales: Sallard, Etienne, Mouthon, Michael, De Pretto, Michael, Spierer, Lucas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874055/
https://www.ncbi.nlm.nih.gov/pubmed/29590181
http://dx.doi.org/10.1371/journal.pone.0194936
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author Sallard, Etienne
Mouthon, Michael
De Pretto, Michael
Spierer, Lucas
author_facet Sallard, Etienne
Mouthon, Michael
De Pretto, Michael
Spierer, Lucas
author_sort Sallard, Etienne
collection PubMed
description Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after right-lateralized prefrontal anodal tDCS with a crossover, sham-controlled, double-blind experimental design. We replicated previous evidence for an absence of offline effect of anodal stimulation on Go/NoGo performance. The fMRI results revealed a larger increase in right ventrolateral prefrontal activity for Go than NoGo trials in the anodal than sham condition. This pattern suggests that tDCS-induced increases in cortical excitability have larger effects on fMRI activity in regions with a lower task-related engagement. This was the case for the right prefrontal cortex in the Go condition in our task because while reactive inhibition was not engaged during execution trials, the unpredictability of the demand for inhibitory control still incited an engagement of proactive inhibition. Exploratory analyses further revealed that right prefrontal stimulation interacted with task-related functional demands in the supplementary motor area and the thalamus. Our collective results emphasize the dependency of offline tDCS functional effects on the task-related engagement of the stimulated areas and suggest that this factor might partly account for the discrepancies in the functional effects of tDCS observed in previous studies.
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spelling pubmed-58740552018-04-06 Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study Sallard, Etienne Mouthon, Michael De Pretto, Michael Spierer, Lucas PLoS One Research Article Prefrontal anodal transcranial direct current stimulation (tDCS) has been proposed as a potential approach to improve inhibitory control performance. The functional consequences of tDCS during inhibition tasks remain, however, largely unresolved. We addressed this question by analyzing functional magnetic resonance imaging (fMRI) recorded while participants completed a Go/NoGo task after right-lateralized prefrontal anodal tDCS with a crossover, sham-controlled, double-blind experimental design. We replicated previous evidence for an absence of offline effect of anodal stimulation on Go/NoGo performance. The fMRI results revealed a larger increase in right ventrolateral prefrontal activity for Go than NoGo trials in the anodal than sham condition. This pattern suggests that tDCS-induced increases in cortical excitability have larger effects on fMRI activity in regions with a lower task-related engagement. This was the case for the right prefrontal cortex in the Go condition in our task because while reactive inhibition was not engaged during execution trials, the unpredictability of the demand for inhibitory control still incited an engagement of proactive inhibition. Exploratory analyses further revealed that right prefrontal stimulation interacted with task-related functional demands in the supplementary motor area and the thalamus. Our collective results emphasize the dependency of offline tDCS functional effects on the task-related engagement of the stimulated areas and suggest that this factor might partly account for the discrepancies in the functional effects of tDCS observed in previous studies. Public Library of Science 2018-03-28 /pmc/articles/PMC5874055/ /pubmed/29590181 http://dx.doi.org/10.1371/journal.pone.0194936 Text en © 2018 Sallard et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sallard, Etienne
Mouthon, Michael
De Pretto, Michael
Spierer, Lucas
Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title_full Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title_fullStr Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title_full_unstemmed Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title_short Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
title_sort modulation of inhibitory control by prefrontal anodal tdcs: a crossover double-blind sham-controlled fmri study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874055/
https://www.ncbi.nlm.nih.gov/pubmed/29590181
http://dx.doi.org/10.1371/journal.pone.0194936
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