Cargando…

Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients

BACKGROUND: Previous studies have established a correlation between coronary artery calcification (CAC) measured by ECG-gated chest computed tomography (CT) and cardiovascular disease. Recent reports which included asymptomatic patients suggest that CAC measured on non-ECG gated CT is similarly asso...

Descripción completa

Detalles Bibliográficos
Autores principales: Lichtenstein, Gabriel, Perlman, Amichai, Shpitzen, Shoshana, Durst, Ronen, Shaham, Dorit, Leitersdorf, Eran, Szalat, Auryan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874063/
https://www.ncbi.nlm.nih.gov/pubmed/29590197
http://dx.doi.org/10.1371/journal.pone.0195061
_version_ 1783310095850930176
author Lichtenstein, Gabriel
Perlman, Amichai
Shpitzen, Shoshana
Durst, Ronen
Shaham, Dorit
Leitersdorf, Eran
Szalat, Auryan
author_facet Lichtenstein, Gabriel
Perlman, Amichai
Shpitzen, Shoshana
Durst, Ronen
Shaham, Dorit
Leitersdorf, Eran
Szalat, Auryan
author_sort Lichtenstein, Gabriel
collection PubMed
description BACKGROUND: Previous studies have established a correlation between coronary artery calcification (CAC) measured by ECG-gated chest computed tomography (CT) and cardiovascular disease. Recent reports which included asymptomatic patients suggest that CAC measured on non-ECG gated CT is similarly associated with cardiovascular risk. This study investigates the correlation between the Framingham Risk Score (FRS) and an incidental finding of CAC on a non-gated chest CT performed for non-cardiac indications in young and seemingly healthy adults. METHODS: A cross-sectional study that included 162 CT scans performed in young patients aged 18–50 years old for non-cardiac indications in our institution was conducted. CAC score (CACS) was calculated using the Agatston method. FRS was calculated and compared to the CACS using three different approaches. The correlations between the CACS and several specific factors (i.e. age, body mass index, smoking, statins, etc.), were also evaluated. RESULTS: Mean age of patients was 36.43 year old and 105 (64.8%) were male. We found a significant positive correlation between the CACS and the FRS in all three approaches (p<0.05). Increased age, smoking and statin use were the only individual factors clearly associated with an increase in CACS (p = 0.002, p = 0.045 and p = 0.009, respectively). CONCLUSION: This is the first report indicating that incidental CACS identified in non-gated MDCT is also associated with cardiovascular risk evaluated by FRS in a young population. Our findings suggest that young asymptomatic individuals with incidental CAC should be seriously evaluated for cardiovascular risk factors despite presumption of belonging to a low cardiovascular risk category.
format Online
Article
Text
id pubmed-5874063
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-58740632018-04-06 Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients Lichtenstein, Gabriel Perlman, Amichai Shpitzen, Shoshana Durst, Ronen Shaham, Dorit Leitersdorf, Eran Szalat, Auryan PLoS One Research Article BACKGROUND: Previous studies have established a correlation between coronary artery calcification (CAC) measured by ECG-gated chest computed tomography (CT) and cardiovascular disease. Recent reports which included asymptomatic patients suggest that CAC measured on non-ECG gated CT is similarly associated with cardiovascular risk. This study investigates the correlation between the Framingham Risk Score (FRS) and an incidental finding of CAC on a non-gated chest CT performed for non-cardiac indications in young and seemingly healthy adults. METHODS: A cross-sectional study that included 162 CT scans performed in young patients aged 18–50 years old for non-cardiac indications in our institution was conducted. CAC score (CACS) was calculated using the Agatston method. FRS was calculated and compared to the CACS using three different approaches. The correlations between the CACS and several specific factors (i.e. age, body mass index, smoking, statins, etc.), were also evaluated. RESULTS: Mean age of patients was 36.43 year old and 105 (64.8%) were male. We found a significant positive correlation between the CACS and the FRS in all three approaches (p<0.05). Increased age, smoking and statin use were the only individual factors clearly associated with an increase in CACS (p = 0.002, p = 0.045 and p = 0.009, respectively). CONCLUSION: This is the first report indicating that incidental CACS identified in non-gated MDCT is also associated with cardiovascular risk evaluated by FRS in a young population. Our findings suggest that young asymptomatic individuals with incidental CAC should be seriously evaluated for cardiovascular risk factors despite presumption of belonging to a low cardiovascular risk category. Public Library of Science 2018-03-28 /pmc/articles/PMC5874063/ /pubmed/29590197 http://dx.doi.org/10.1371/journal.pone.0195061 Text en © 2018 Lichtenstein et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Lichtenstein, Gabriel
Perlman, Amichai
Shpitzen, Shoshana
Durst, Ronen
Shaham, Dorit
Leitersdorf, Eran
Szalat, Auryan
Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title_full Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title_fullStr Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title_full_unstemmed Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title_short Correlation between coronary artery calcification by non-cardiac CT and Framingham score in young patients
title_sort correlation between coronary artery calcification by non-cardiac ct and framingham score in young patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874063/
https://www.ncbi.nlm.nih.gov/pubmed/29590197
http://dx.doi.org/10.1371/journal.pone.0195061
work_keys_str_mv AT lichtensteingabriel correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT perlmanamichai correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT shpitzenshoshana correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT durstronen correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT shahamdorit correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT leitersdorferan correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients
AT szalatauryan correlationbetweencoronaryarterycalcificationbynoncardiacctandframinghamscoreinyoungpatients