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MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study

Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both in space, since the pancreas is located in proximity to radiosensitive vital organs, and in time as it is s...

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Autores principales: Fontana, Giulia, Riboldi, Marco, Gianoli, Chiara, Chirvase, Cezarina I., Villa, Gaetano, Paganelli, Chiara, Summers, Paul E., Tagaste, Barbara, Pella, Andrea, Fossati, Piero, Ciocca, Mario, Baroni, Guido, Valvo, Francesca, Orecchia, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874090/
https://www.ncbi.nlm.nih.gov/pubmed/27685119
http://dx.doi.org/10.1120/jacmp.v17i5.6236
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author Fontana, Giulia
Riboldi, Marco
Gianoli, Chiara
Chirvase, Cezarina I.
Villa, Gaetano
Paganelli, Chiara
Summers, Paul E.
Tagaste, Barbara
Pella, Andrea
Fossati, Piero
Ciocca, Mario
Baroni, Guido
Valvo, Francesca
Orecchia, Roberto
author_facet Fontana, Giulia
Riboldi, Marco
Gianoli, Chiara
Chirvase, Cezarina I.
Villa, Gaetano
Paganelli, Chiara
Summers, Paul E.
Tagaste, Barbara
Pella, Andrea
Fossati, Piero
Ciocca, Mario
Baroni, Guido
Valvo, Francesca
Orecchia, Roberto
author_sort Fontana, Giulia
collection PubMed
description Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both in space, since the pancreas is located in proximity to radiosensitive vital organs, and in time as it is subject to substantial breathing‐related motion. The purpose of this preliminary study was to quantify pancreas range of motion under typical PT treatment conditions. Three common immobilization devices (vacuum cushion, thermoplastic mask, and compressor belt) were evaluated on five male patients in prone and supine positions. Retrospective four‐dimensional magnetic resonance imaging data were reconstructed for each condition and the pancreas was manually segmented on each of six breathing phases. A k‐means algorithm was then applied on the manually segmented map in order to obtain clusters representative of the three pancreas segments: head, body, and tail. Centers of mass (COM) for the pancreas and its segments were computed, as well as their displacements with respect to a reference breathing phase (beginning exhalation). The median three‐dimensional COM displacements were in the range of 3 mm. Latero–lateral and superior–inferior directions had a higher range of motion than the anterior–posterior direction. Motion analysis of the pancreas segments showed slightly lower COM displacements for the head cluster compared to the tail cluster, especially in prone position. Statistically significant differences were found within patients among the investigated setups. Hence a patient‐specific approach, rather than a general strategy, is suggested to define the optimal treatment setup in the frame of a millimeter positioning accuracy. PACS number(s): 87.55.‐x, 87.57.nm, 87.61
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spelling pubmed-58740902018-04-02 MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study Fontana, Giulia Riboldi, Marco Gianoli, Chiara Chirvase, Cezarina I. Villa, Gaetano Paganelli, Chiara Summers, Paul E. Tagaste, Barbara Pella, Andrea Fossati, Piero Ciocca, Mario Baroni, Guido Valvo, Francesca Orecchia, Roberto J Appl Clin Med Phys Radiation Oncology Physics Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both in space, since the pancreas is located in proximity to radiosensitive vital organs, and in time as it is subject to substantial breathing‐related motion. The purpose of this preliminary study was to quantify pancreas range of motion under typical PT treatment conditions. Three common immobilization devices (vacuum cushion, thermoplastic mask, and compressor belt) were evaluated on five male patients in prone and supine positions. Retrospective four‐dimensional magnetic resonance imaging data were reconstructed for each condition and the pancreas was manually segmented on each of six breathing phases. A k‐means algorithm was then applied on the manually segmented map in order to obtain clusters representative of the three pancreas segments: head, body, and tail. Centers of mass (COM) for the pancreas and its segments were computed, as well as their displacements with respect to a reference breathing phase (beginning exhalation). The median three‐dimensional COM displacements were in the range of 3 mm. Latero–lateral and superior–inferior directions had a higher range of motion than the anterior–posterior direction. Motion analysis of the pancreas segments showed slightly lower COM displacements for the head cluster compared to the tail cluster, especially in prone position. Statistically significant differences were found within patients among the investigated setups. Hence a patient‐specific approach, rather than a general strategy, is suggested to define the optimal treatment setup in the frame of a millimeter positioning accuracy. PACS number(s): 87.55.‐x, 87.57.nm, 87.61 John Wiley and Sons Inc. 2016-09-08 /pmc/articles/PMC5874090/ /pubmed/27685119 http://dx.doi.org/10.1120/jacmp.v17i5.6236 Text en © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Fontana, Giulia
Riboldi, Marco
Gianoli, Chiara
Chirvase, Cezarina I.
Villa, Gaetano
Paganelli, Chiara
Summers, Paul E.
Tagaste, Barbara
Pella, Andrea
Fossati, Piero
Ciocca, Mario
Baroni, Guido
Valvo, Francesca
Orecchia, Roberto
MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title_full MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title_fullStr MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title_full_unstemmed MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title_short MRI quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
title_sort mri quantification of pancreas motion as a function of patient setup for particle therapy —a preliminary study
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874090/
https://www.ncbi.nlm.nih.gov/pubmed/27685119
http://dx.doi.org/10.1120/jacmp.v17i5.6236
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