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Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface
Presence of interfaces between high and low atomic number (Z) materials, often encountered in diagnostic imaging and radiation therapy, leads to radiation dose perturbation. It is characterized by a very narrow region of sharp dose enhancement at the interface. A rapid falloff of dose enhancement ov...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874124/ https://www.ncbi.nlm.nih.gov/pubmed/27685139 http://dx.doi.org/10.1120/jacmp.v17i5.6339 |
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author | Paudel, Nava Raj Shvydka, Diana Parsai, E. Ishmael |
author_facet | Paudel, Nava Raj Shvydka, Diana Parsai, E. Ishmael |
author_sort | Paudel, Nava Raj |
collection | PubMed |
description | Presence of interfaces between high and low atomic number (Z) materials, often encountered in diagnostic imaging and radiation therapy, leads to radiation dose perturbation. It is characterized by a very narrow region of sharp dose enhancement at the interface. A rapid falloff of dose enhancement over a very short distance from the interface makes the experimental dosimetry nontrivial. We use an in‐house‐built inexpensive thin‐film Cadmium Telluride (CdTe) photodetector to study this effect at the gold‐tissue interface and verify our experimental results with Monte Carlo (MC) modeling. Three‐micron thick thin‐film CdTe photodetectors were fabricated in our lab. One‐, ten‐ or one hundred‐micron thick gold foils placed in a tissue‐equivalent‐phantom were irradiated with a clinical Ir‐192 high‐dose‐rate (HDR) source and current measured with a CdTe detector in each case was compared with the current measured for all uniform tissue‐equivalent phantom. Percentage signal enhancement (PSE) due to each gold foil was then compared against MC modeled percentage dose enhancement (PDE), obtained from the geometry mimicking the experimental setup. The experimental PSEs due to 1, 10, and [Formula: see text] thick gold foils at the closest measured distance of [Formula: see text] from the interface were [Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively. The corresponding MC modeled PDEs were [Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively. The experimental and MC modeled values showed a closer agreement at the larger distances from the interface. The dose enhancement in the vicinity of gold‐tissue interface was successfully measured using an in‐house‐built, high‐resolution CdTe‐based photodetector and validated with MC simulations. A close agreement between experimental and the MC modeled results shows that CdTe detector can be utilized for mapping interface dose distribution encountered in the application of ionizing radiation. PACS number(s): 29.40.Wk, 73.50.Pz, 87.53.Jw, 87.55.K‐ |
format | Online Article Text |
id | pubmed-5874124 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58741242018-04-02 Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface Paudel, Nava Raj Shvydka, Diana Parsai, E. Ishmael J Appl Clin Med Phys Radiation Measurements Presence of interfaces between high and low atomic number (Z) materials, often encountered in diagnostic imaging and radiation therapy, leads to radiation dose perturbation. It is characterized by a very narrow region of sharp dose enhancement at the interface. A rapid falloff of dose enhancement over a very short distance from the interface makes the experimental dosimetry nontrivial. We use an in‐house‐built inexpensive thin‐film Cadmium Telluride (CdTe) photodetector to study this effect at the gold‐tissue interface and verify our experimental results with Monte Carlo (MC) modeling. Three‐micron thick thin‐film CdTe photodetectors were fabricated in our lab. One‐, ten‐ or one hundred‐micron thick gold foils placed in a tissue‐equivalent‐phantom were irradiated with a clinical Ir‐192 high‐dose‐rate (HDR) source and current measured with a CdTe detector in each case was compared with the current measured for all uniform tissue‐equivalent phantom. Percentage signal enhancement (PSE) due to each gold foil was then compared against MC modeled percentage dose enhancement (PDE), obtained from the geometry mimicking the experimental setup. The experimental PSEs due to 1, 10, and [Formula: see text] thick gold foils at the closest measured distance of [Formula: see text] from the interface were [Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively. The corresponding MC modeled PDEs were [Formula: see text] , [Formula: see text] , and [Formula: see text] , respectively. The experimental and MC modeled values showed a closer agreement at the larger distances from the interface. The dose enhancement in the vicinity of gold‐tissue interface was successfully measured using an in‐house‐built, high‐resolution CdTe‐based photodetector and validated with MC simulations. A close agreement between experimental and the MC modeled results shows that CdTe detector can be utilized for mapping interface dose distribution encountered in the application of ionizing radiation. PACS number(s): 29.40.Wk, 73.50.Pz, 87.53.Jw, 87.55.K‐ John Wiley and Sons Inc. 2016-09-08 /pmc/articles/PMC5874124/ /pubmed/27685139 http://dx.doi.org/10.1120/jacmp.v17i5.6339 Text en © 2016 The Authors. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/3.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Measurements Paudel, Nava Raj Shvydka, Diana Parsai, E. Ishmael Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title | Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title_full | Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title_fullStr | Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title_full_unstemmed | Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title_short | Thin‐film CdTe detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
title_sort | thin‐film cdte detector for microdosimetric study of radiation dose enhancement at gold‐tissue interface |
topic | Radiation Measurements |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874124/ https://www.ncbi.nlm.nih.gov/pubmed/27685139 http://dx.doi.org/10.1120/jacmp.v17i5.6339 |
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