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Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial
Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determin...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
the Society for Free Radical Research Japan
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874231/ https://www.ncbi.nlm.nih.gov/pubmed/29610558 http://dx.doi.org/10.3164/jcbn.17-46 |
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author | Iguchi, Munetaka Kakimoto, Kazuki Kuramoto, Takanori Nakazawa, Kei Kubota, Minori Hirata, Yuki Fujiwara, Kaori Harada, Satoshi Sakanaka, Taisuke Ota, Kazuhiro Edogawa, Shoko Kojima, Yuichi Nouda, Sadaharu Okada, Toshihiko Kawakami, Ken Takeuchi, Toshihisa Inoue, Takuya Higuchi, Kazuhide |
author_facet | Iguchi, Munetaka Kakimoto, Kazuki Kuramoto, Takanori Nakazawa, Kei Kubota, Minori Hirata, Yuki Fujiwara, Kaori Harada, Satoshi Sakanaka, Taisuke Ota, Kazuhiro Edogawa, Shoko Kojima, Yuichi Nouda, Sadaharu Okada, Toshihiko Kawakami, Ken Takeuchi, Toshihisa Inoue, Takuya Higuchi, Kazuhide |
author_sort | Iguchi, Munetaka |
collection | PubMed |
description | Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated the preventative effect of egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against small-intestinal mucosal damage induced by low-dose aspirin in healthy adult male volunteers. Participants were randomly allocated to receive aspirin 100 mg/kg daily (control group, n = 10) or aspirin 100 mg/kg plus egualen sodium 30 mg daily (egualen sodium group, n = 10). Small intestinal mucosal injury was evaluated by capsule endoscopy two weeks after initiation of drug administration. Fecal analyses (occult blood test, immunochemical test, transferrin measurement and calprotectin measurement) were carried out before and after treatment. Egualen sodium significantly suppressed the total number of small intestinal injuries detected by capsule endoscopy and the positive ratio for the fecal occult blood test. Daily use of 30 mg of egualen sodium showed a preventative effect on low-dose aspirin-induced small intestinal injury. Since acid suppression therapy was reported to exacerbate NSAIDs-induced enteropathy via dysbiosis, egualen sodium may be useful for patients treated with low-dose aspirin. |
format | Online Article Text |
id | pubmed-5874231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | the Society for Free Radical Research Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-58742312018-04-02 Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial Iguchi, Munetaka Kakimoto, Kazuki Kuramoto, Takanori Nakazawa, Kei Kubota, Minori Hirata, Yuki Fujiwara, Kaori Harada, Satoshi Sakanaka, Taisuke Ota, Kazuhiro Edogawa, Shoko Kojima, Yuichi Nouda, Sadaharu Okada, Toshihiko Kawakami, Ken Takeuchi, Toshihisa Inoue, Takuya Higuchi, Kazuhide J Clin Biochem Nutr Original Article Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated the preventative effect of egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against small-intestinal mucosal damage induced by low-dose aspirin in healthy adult male volunteers. Participants were randomly allocated to receive aspirin 100 mg/kg daily (control group, n = 10) or aspirin 100 mg/kg plus egualen sodium 30 mg daily (egualen sodium group, n = 10). Small intestinal mucosal injury was evaluated by capsule endoscopy two weeks after initiation of drug administration. Fecal analyses (occult blood test, immunochemical test, transferrin measurement and calprotectin measurement) were carried out before and after treatment. Egualen sodium significantly suppressed the total number of small intestinal injuries detected by capsule endoscopy and the positive ratio for the fecal occult blood test. Daily use of 30 mg of egualen sodium showed a preventative effect on low-dose aspirin-induced small intestinal injury. Since acid suppression therapy was reported to exacerbate NSAIDs-induced enteropathy via dysbiosis, egualen sodium may be useful for patients treated with low-dose aspirin. the Society for Free Radical Research Japan 2018-03 2018-01-11 /pmc/articles/PMC5874231/ /pubmed/29610558 http://dx.doi.org/10.3164/jcbn.17-46 Text en Copyright © 2018 JCBN http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Iguchi, Munetaka Kakimoto, Kazuki Kuramoto, Takanori Nakazawa, Kei Kubota, Minori Hirata, Yuki Fujiwara, Kaori Harada, Satoshi Sakanaka, Taisuke Ota, Kazuhiro Edogawa, Shoko Kojima, Yuichi Nouda, Sadaharu Okada, Toshihiko Kawakami, Ken Takeuchi, Toshihisa Inoue, Takuya Higuchi, Kazuhide Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title | Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title_full | Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title_fullStr | Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title_full_unstemmed | Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title_short | Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
title_sort | effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874231/ https://www.ncbi.nlm.nih.gov/pubmed/29610558 http://dx.doi.org/10.3164/jcbn.17-46 |
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