Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

Genome-wide association studies (GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal...

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Detalles Bibliográficos
Autores principales: Carey, Heather A., Hildreth, Blake E., Geisler, Jennifer A., Nickel, Mara C., Cabrera, Jennifer, Ghosh, Sankha, Jiang, Yue, Yan, Jing, Lee, James, Makam, Sandeep, Young, Nicholas A., Valiente, Giancarlo R., Jarjour, Wael N., Huang, Kun, Rosol, Thomas J., Toribio, Ramiro E., Charles, Julia F., Ostrowski, Michael C., Sharma, Sudarshana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874256/
https://www.ncbi.nlm.nih.gov/pubmed/29619268
http://dx.doi.org/10.1038/s41413-018-0011-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874256/
https://www.ncbi.nlm.nih.gov/pubmed/29619268
http://dx.doi.org/10.1038/s41413-018-0011-1

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