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Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients

Thrombosis is one of the leading causes of mortality in cancer patients. The aim of the study was to evaluate the concentrations and activities of selected haemostatic parameters in the plasma of patients diagnosed with breast cancer (BrCa) and to make an attempt at finding associations with their l...

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Autores principales: Rhone, Piotr, Ruszkowska-Ciastek, Barbara, Bielawski, Kornel, Brkic, Alen, Zarychta, Elżbieta, Góralczyk, Barbara, Roszkowski, Krzysztof, Rość, Danuta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874264/
https://www.ncbi.nlm.nih.gov/pubmed/29475895
http://dx.doi.org/10.1042/BSR20171657
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author Rhone, Piotr
Ruszkowska-Ciastek, Barbara
Bielawski, Kornel
Brkic, Alen
Zarychta, Elżbieta
Góralczyk, Barbara
Roszkowski, Krzysztof
Rość, Danuta
author_facet Rhone, Piotr
Ruszkowska-Ciastek, Barbara
Bielawski, Kornel
Brkic, Alen
Zarychta, Elżbieta
Góralczyk, Barbara
Roszkowski, Krzysztof
Rość, Danuta
author_sort Rhone, Piotr
collection PubMed
description Thrombosis is one of the leading causes of mortality in cancer patients. The aim of the study was to evaluate the concentrations and activities of selected haemostatic parameters in the plasma of patients diagnosed with breast cancer (BrCa) and to make an attempt at finding associations with their levels and selected clinicopathological factors; clinical classification, histological grading, and molecular subtype of BrCa. The study involved 145 Caucasian ethnicity women. Eighty-five women aged 45–66 with primary BrCa without distant metastases (M0). Inclusion criteria were as follows: histopathological examination confirming the diagnosis of primary BrCa, without previous radiotherapy and chemotherapy. The control group consisted of 60, post-menopausal women, aged 45–68. Haemostatic profile expressed by concentrations and activities of tissue factor (TF) and its inhibitor (TFPI) as well as concentrations of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) were measured applying immunoassay techniques. A significantly higher concentration of PAI-1 was noted in patients with BrCa localized in the left breast. We observed significantly lower activity of TFPI and significantly higher concentration of PAI-1 in the group of patients with invasive ductal carcinoma as compared with invasive lobular carcinoma. A significantly higher concentration of t-PA in patients with pT2 BrCa in relation to pT1 cases was noted. Based on comprehensive analysis of haemostatic profile depending on clinicopathological features, we suggest that haemostatic parameters play crucial roles in invasion and metastases of malignant tumours.
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spelling pubmed-58742642018-04-05 Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients Rhone, Piotr Ruszkowska-Ciastek, Barbara Bielawski, Kornel Brkic, Alen Zarychta, Elżbieta Góralczyk, Barbara Roszkowski, Krzysztof Rość, Danuta Biosci Rep Research Articles Thrombosis is one of the leading causes of mortality in cancer patients. The aim of the study was to evaluate the concentrations and activities of selected haemostatic parameters in the plasma of patients diagnosed with breast cancer (BrCa) and to make an attempt at finding associations with their levels and selected clinicopathological factors; clinical classification, histological grading, and molecular subtype of BrCa. The study involved 145 Caucasian ethnicity women. Eighty-five women aged 45–66 with primary BrCa without distant metastases (M0). Inclusion criteria were as follows: histopathological examination confirming the diagnosis of primary BrCa, without previous radiotherapy and chemotherapy. The control group consisted of 60, post-menopausal women, aged 45–68. Haemostatic profile expressed by concentrations and activities of tissue factor (TF) and its inhibitor (TFPI) as well as concentrations of tissue plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) were measured applying immunoassay techniques. A significantly higher concentration of PAI-1 was noted in patients with BrCa localized in the left breast. We observed significantly lower activity of TFPI and significantly higher concentration of PAI-1 in the group of patients with invasive ductal carcinoma as compared with invasive lobular carcinoma. A significantly higher concentration of t-PA in patients with pT2 BrCa in relation to pT1 cases was noted. Based on comprehensive analysis of haemostatic profile depending on clinicopathological features, we suggest that haemostatic parameters play crucial roles in invasion and metastases of malignant tumours. Portland Press Ltd. 2018-03-29 /pmc/articles/PMC5874264/ /pubmed/29475895 http://dx.doi.org/10.1042/BSR20171657 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Rhone, Piotr
Ruszkowska-Ciastek, Barbara
Bielawski, Kornel
Brkic, Alen
Zarychta, Elżbieta
Góralczyk, Barbara
Roszkowski, Krzysztof
Rość, Danuta
Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title_full Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title_fullStr Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title_full_unstemmed Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title_short Comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
title_sort comprehensive analysis of haemostatic profile depending on clinicopathological determinants in breast cancer patients
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874264/
https://www.ncbi.nlm.nih.gov/pubmed/29475895
http://dx.doi.org/10.1042/BSR20171657
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