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Predictability and Resetting in a Case of Convulsive Status Epilepticus
In this case study, we present evidence of resetting of brain dynamics following convulsive status epilepticus (SE) that was treated successfully with antiepileptic medications (AEDs). The measure of effective inflow (EI), a novel measure of network connectivity, was applied to the continuously reco...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874309/ https://www.ncbi.nlm.nih.gov/pubmed/29623064 http://dx.doi.org/10.3389/fneur.2018.00172 |
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author | Hutson, Timothy Pizarro, Diana Pati, Sandipan Iasemidis, Leon D. |
author_facet | Hutson, Timothy Pizarro, Diana Pati, Sandipan Iasemidis, Leon D. |
author_sort | Hutson, Timothy |
collection | PubMed |
description | In this case study, we present evidence of resetting of brain dynamics following convulsive status epilepticus (SE) that was treated successfully with antiepileptic medications (AEDs). The measure of effective inflow (EI), a novel measure of network connectivity, was applied to the continuously recorded multichannel intracranial stereoelectroencephalographic (SEEG) signals before, during and after SE. Results from this analysis indicate trends of progressive reduction of EI over hours up to the onset of SE, mainly at sites of the epileptogenic focus with reversal of those trends upon successful treatment of SE by AEDs. The proposed analytical framework is promising for elucidation of the pathology of neuronal network dynamics that could lead to SE, evaluation of the efficacy of SE treatment strategies, as well as the development of biomarkers for susceptibility to SE. |
format | Online Article Text |
id | pubmed-5874309 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58743092018-04-05 Predictability and Resetting in a Case of Convulsive Status Epilepticus Hutson, Timothy Pizarro, Diana Pati, Sandipan Iasemidis, Leon D. Front Neurol Neuroscience In this case study, we present evidence of resetting of brain dynamics following convulsive status epilepticus (SE) that was treated successfully with antiepileptic medications (AEDs). The measure of effective inflow (EI), a novel measure of network connectivity, was applied to the continuously recorded multichannel intracranial stereoelectroencephalographic (SEEG) signals before, during and after SE. Results from this analysis indicate trends of progressive reduction of EI over hours up to the onset of SE, mainly at sites of the epileptogenic focus with reversal of those trends upon successful treatment of SE by AEDs. The proposed analytical framework is promising for elucidation of the pathology of neuronal network dynamics that could lead to SE, evaluation of the efficacy of SE treatment strategies, as well as the development of biomarkers for susceptibility to SE. Frontiers Media S.A. 2018-03-22 /pmc/articles/PMC5874309/ /pubmed/29623064 http://dx.doi.org/10.3389/fneur.2018.00172 Text en Copyright © 2018 Hutson, Pizarro, Pati and Iasemidis. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Hutson, Timothy Pizarro, Diana Pati, Sandipan Iasemidis, Leon D. Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title | Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title_full | Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title_fullStr | Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title_full_unstemmed | Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title_short | Predictability and Resetting in a Case of Convulsive Status Epilepticus |
title_sort | predictability and resetting in a case of convulsive status epilepticus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874309/ https://www.ncbi.nlm.nih.gov/pubmed/29623064 http://dx.doi.org/10.3389/fneur.2018.00172 |
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