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Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules
A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874344/ https://www.ncbi.nlm.nih.gov/pubmed/29093420 http://dx.doi.org/10.2169/internalmedicine.9399-17 |
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author | Numata, Takeshi Hida, Norihito Yazaki, Kai Arai, Naoki Ota, Kyoko Yanai, Hidetoshi Endo, Takeo |
author_facet | Numata, Takeshi Hida, Norihito Yazaki, Kai Arai, Naoki Ota, Kyoko Yanai, Hidetoshi Endo, Takeo |
author_sort | Numata, Takeshi |
collection | PubMed |
description | A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields. Her bronchoalveolar lavage fluid contained an unusually high number of lymphocytes, and a drug-induced lymphocyte stimulation test for seasonal influenza vaccine was positive. Transbronchial lung biopsy revealed the presence of granulomatous inflammation. Thereafter her abnormal chest shadow spontaneously improved. Based on these findings, the patient was diagnosed with drug-induced pneumonitis due to an influenza vaccine. |
format | Online Article Text |
id | pubmed-5874344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-58743442018-03-29 Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules Numata, Takeshi Hida, Norihito Yazaki, Kai Arai, Naoki Ota, Kyoko Yanai, Hidetoshi Endo, Takeo Intern Med Case Report A 39-year-old woman received a seasonal influenza vaccine in November 2015 and subsequently experienced malaise, low-grade fever, and chest discomfort. A chest X-ray performed 2 weeks after vaccination showed multiple nodular shadows in both lungs and ground-glass shadows in both lower lung fields. Her bronchoalveolar lavage fluid contained an unusually high number of lymphocytes, and a drug-induced lymphocyte stimulation test for seasonal influenza vaccine was positive. Transbronchial lung biopsy revealed the presence of granulomatous inflammation. Thereafter her abnormal chest shadow spontaneously improved. Based on these findings, the patient was diagnosed with drug-induced pneumonitis due to an influenza vaccine. The Japanese Society of Internal Medicine 2017-11-01 2018-03-01 /pmc/articles/PMC5874344/ /pubmed/29093420 http://dx.doi.org/10.2169/internalmedicine.9399-17 Text en Copyright © 2018 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Numata, Takeshi Hida, Norihito Yazaki, Kai Arai, Naoki Ota, Kyoko Yanai, Hidetoshi Endo, Takeo Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title | Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title_full | Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title_fullStr | Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title_full_unstemmed | Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title_short | Seasonal Influenza Vaccine-induced Pneumonitis Presenting with Multiple Pulmonary Nodules |
title_sort | seasonal influenza vaccine-induced pneumonitis presenting with multiple pulmonary nodules |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874344/ https://www.ncbi.nlm.nih.gov/pubmed/29093420 http://dx.doi.org/10.2169/internalmedicine.9399-17 |
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