Further Evidence of Accelerated Aging in Bipolar Disorder: Focus on GDF-15

BACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients a...

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Detalles Bibliográficos
Autores principales: Yang, Fang, Barbosa, Izabela G., Vieira, Erica L., Bauer, Moises E., Rocha, Natalia P., Teixeira, Antonio L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2018
Materias:
Regular Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874508/
https://www.ncbi.nlm.nih.gov/pubmed/29607212
http://dx.doi.org/10.1515/tnsci-2018-0004
Descripción
Sumario:BACKGROUND: Bipolar disorder (BD) is a mood disorder associated with cardiovascular and metabolic diseases and premature aging. Growth differentiation factor 15 (GDF-15) has emerged as a biomarker for cardiovascular risk and aging. Our aim was to compare plasma levels of GDF-15 between BD patients and controls, and to evaluate whether they were associated with clinical parameters. METHODS: Forty-six patients with type I BD (23 in euthymia and 23 in mania) and 33 healthy controls were recruited for this study. Plasma levels of GDF-15 were measured by immunoassay. RESULTS: The levels of GDF-15 were significantly higher (p < 0.001) in patients with BD in comparison with controls. In patients, GDF-15 levels correlated with age (rho = 0.434; p = 0.003) and illness duration (rho = 0.502; p = 0.001). CONCLUSION: Our findings corroborate the view that BD is an illness associated with accelerated aging.

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