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Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression

Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhi...

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Autores principales: Zhang, Lin, Li, Kailong, Zhang, Chengqi, Qi, Xianlong, Zheng, Ning, Wang, Guangbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter Open 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874511/
https://www.ncbi.nlm.nih.gov/pubmed/29607418
http://dx.doi.org/10.1515/med-2018-0014
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author Zhang, Lin
Li, Kailong
Zhang, Chengqi
Qi, Xianlong
Zheng, Ning
Wang, Guangbin
author_facet Zhang, Lin
Li, Kailong
Zhang, Chengqi
Qi, Xianlong
Zheng, Ning
Wang, Guangbin
author_sort Zhang, Lin
collection PubMed
description Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation. Subsequently, the data were analyzed by using IBM SPSS Statistics 22. Results: Compared with TD children, a significant reduction of FA along with an increase in TV and NV was observed in ASD children with language regression. Note that there were no significant differences between ASD and TD children in AFL of the arcuate fasciculus (AF). Conclusions: These DTI changes in the AF suggest that microstructural anomalies of the AF white matter may be associated with language deficits in ASD children exhibiting language regression starting from an early age.
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spelling pubmed-58745112018-03-30 Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression Zhang, Lin Li, Kailong Zhang, Chengqi Qi, Xianlong Zheng, Ning Wang, Guangbin Open Med (Wars) Regular Articles Language regression is observed in a subset of toddlers with autism spectrum disorder (ASD) as initial symptom. However, such a phenomenon has not been fully explored, partly due to the lack of definite diagnostic evaluation methods and criteria. Materials and Methods: Fifteen toddlers with ASD exhibiting language regression and fourteen age-matched typically developing (TD) controls underwent diffusion tensor imaging (DTI). DTI parameters including fractional anisotropy (FA), average fiber length (AFL), tract volume (TV) and number of voxels (NV) were analyzed by Neuro 3D in Siemens syngo workstation. Subsequently, the data were analyzed by using IBM SPSS Statistics 22. Results: Compared with TD children, a significant reduction of FA along with an increase in TV and NV was observed in ASD children with language regression. Note that there were no significant differences between ASD and TD children in AFL of the arcuate fasciculus (AF). Conclusions: These DTI changes in the AF suggest that microstructural anomalies of the AF white matter may be associated with language deficits in ASD children exhibiting language regression starting from an early age. De Gruyter Open 2018-03-21 /pmc/articles/PMC5874511/ /pubmed/29607418 http://dx.doi.org/10.1515/med-2018-0014 Text en © 2018 Lin Zhang et al. http://creativecommons.org/licenses/by-nc-nd/4.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
spellingShingle Regular Articles
Zhang, Lin
Li, Kailong
Zhang, Chengqi
Qi, Xianlong
Zheng, Ning
Wang, Guangbin
Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title_full Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title_fullStr Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title_full_unstemmed Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title_short Arcuate Fasciculus in Autism Spectrum Disorder Toddlers with Language Regression
title_sort arcuate fasciculus in autism spectrum disorder toddlers with language regression
topic Regular Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874511/
https://www.ncbi.nlm.nih.gov/pubmed/29607418
http://dx.doi.org/10.1515/med-2018-0014
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