Cargando…

Selenium and Selenoproteins in Gut Inflammation—A Review

Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the a...

Descripción completa

Detalles Bibliográficos
Autores principales: Nettleford, Shaneice K., Prabhu, K. Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874522/
https://www.ncbi.nlm.nih.gov/pubmed/29494512
http://dx.doi.org/10.3390/antiox7030036
_version_ 1783310170510589952
author Nettleford, Shaneice K.
Prabhu, K. Sandeep
author_facet Nettleford, Shaneice K.
Prabhu, K. Sandeep
author_sort Nettleford, Shaneice K.
collection PubMed
description Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD.
format Online
Article
Text
id pubmed-5874522
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58745222018-04-02 Selenium and Selenoproteins in Gut Inflammation—A Review Nettleford, Shaneice K. Prabhu, K. Sandeep Antioxidants (Basel) Review Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD. MDPI 2018-03-01 /pmc/articles/PMC5874522/ /pubmed/29494512 http://dx.doi.org/10.3390/antiox7030036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nettleford, Shaneice K.
Prabhu, K. Sandeep
Selenium and Selenoproteins in Gut Inflammation—A Review
title Selenium and Selenoproteins in Gut Inflammation—A Review
title_full Selenium and Selenoproteins in Gut Inflammation—A Review
title_fullStr Selenium and Selenoproteins in Gut Inflammation—A Review
title_full_unstemmed Selenium and Selenoproteins in Gut Inflammation—A Review
title_short Selenium and Selenoproteins in Gut Inflammation—A Review
title_sort selenium and selenoproteins in gut inflammation—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874522/
https://www.ncbi.nlm.nih.gov/pubmed/29494512
http://dx.doi.org/10.3390/antiox7030036
work_keys_str_mv AT nettlefordshaneicek seleniumandselenoproteinsingutinflammationareview
AT prabhuksandeep seleniumandselenoproteinsingutinflammationareview