Cargando…
Selenium and Selenoproteins in Gut Inflammation—A Review
Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the a...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874522/ https://www.ncbi.nlm.nih.gov/pubmed/29494512 http://dx.doi.org/10.3390/antiox7030036 |
_version_ | 1783310170510589952 |
---|---|
author | Nettleford, Shaneice K. Prabhu, K. Sandeep |
author_facet | Nettleford, Shaneice K. Prabhu, K. Sandeep |
author_sort | Nettleford, Shaneice K. |
collection | PubMed |
description | Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD. |
format | Online Article Text |
id | pubmed-5874522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58745222018-04-02 Selenium and Selenoproteins in Gut Inflammation—A Review Nettleford, Shaneice K. Prabhu, K. Sandeep Antioxidants (Basel) Review Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD. MDPI 2018-03-01 /pmc/articles/PMC5874522/ /pubmed/29494512 http://dx.doi.org/10.3390/antiox7030036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nettleford, Shaneice K. Prabhu, K. Sandeep Selenium and Selenoproteins in Gut Inflammation—A Review |
title | Selenium and Selenoproteins in Gut Inflammation—A Review |
title_full | Selenium and Selenoproteins in Gut Inflammation—A Review |
title_fullStr | Selenium and Selenoproteins in Gut Inflammation—A Review |
title_full_unstemmed | Selenium and Selenoproteins in Gut Inflammation—A Review |
title_short | Selenium and Selenoproteins in Gut Inflammation—A Review |
title_sort | selenium and selenoproteins in gut inflammation—a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874522/ https://www.ncbi.nlm.nih.gov/pubmed/29494512 http://dx.doi.org/10.3390/antiox7030036 |
work_keys_str_mv | AT nettlefordshaneicek seleniumandselenoproteinsingutinflammationareview AT prabhuksandeep seleniumandselenoproteinsingutinflammationareview |