Cargando…

Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines

Preventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Du...

Descripción completa

Detalles Bibliográficos
Autores principales: Köck, Robin, Siemer, Philipp, Esser, Jutta, Kampmeier, Stefanie, Berends, Matthijs S., Glasner, Corinna, Arends, Jan P., Becker, Karsten, Friedrich, Alexander W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874625/
https://www.ncbi.nlm.nih.gov/pubmed/29373498
http://dx.doi.org/10.3390/microorganisms6010011
_version_ 1783310194605817856
author Köck, Robin
Siemer, Philipp
Esser, Jutta
Kampmeier, Stefanie
Berends, Matthijs S.
Glasner, Corinna
Arends, Jan P.
Becker, Karsten
Friedrich, Alexander W.
author_facet Köck, Robin
Siemer, Philipp
Esser, Jutta
Kampmeier, Stefanie
Berends, Matthijs S.
Glasner, Corinna
Arends, Jan P.
Becker, Karsten
Friedrich, Alexander W.
author_sort Köck, Robin
collection PubMed
description Preventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Dutch–German border region, where patients are transferred between healthcare facilities located in the two different countries, because clinicians and infection control personnel must understand antibiograms indicating MDRGNB from both sides of the border and using both national guidelines. This retrospective study aimed to compare antibiograms of Gram-negative bacteria and classify them using the Dutch and German national standards for MDRGNB definition. A total of 31,787 antibiograms from six Dutch and four German hospitals were classified. Overall, 73.7% were no MDRGNB according to both guidelines. According to the Dutch and German guideline, 7772/31,787 (24.5%) and 4586/31,787 (12.9%) were MDRGNB, respectively (p < 0.0001). Major divergent classifications were observed for extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae, non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. The observed differences show that medical staff must carefully check previous diagnostic findings when patients are transferred across the Dutch–German border, as it cannot be assumed that MDRGNB requiring special hygiene precautions are marked in the transferred antibiograms in accordance with both national guidelines.
format Online
Article
Text
id pubmed-5874625
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-58746252018-04-02 Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines Köck, Robin Siemer, Philipp Esser, Jutta Kampmeier, Stefanie Berends, Matthijs S. Glasner, Corinna Arends, Jan P. Becker, Karsten Friedrich, Alexander W. Microorganisms Article Preventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Dutch–German border region, where patients are transferred between healthcare facilities located in the two different countries, because clinicians and infection control personnel must understand antibiograms indicating MDRGNB from both sides of the border and using both national guidelines. This retrospective study aimed to compare antibiograms of Gram-negative bacteria and classify them using the Dutch and German national standards for MDRGNB definition. A total of 31,787 antibiograms from six Dutch and four German hospitals were classified. Overall, 73.7% were no MDRGNB according to both guidelines. According to the Dutch and German guideline, 7772/31,787 (24.5%) and 4586/31,787 (12.9%) were MDRGNB, respectively (p < 0.0001). Major divergent classifications were observed for extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae, non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. The observed differences show that medical staff must carefully check previous diagnostic findings when patients are transferred across the Dutch–German border, as it cannot be assumed that MDRGNB requiring special hygiene precautions are marked in the transferred antibiograms in accordance with both national guidelines. MDPI 2018-01-26 /pmc/articles/PMC5874625/ /pubmed/29373498 http://dx.doi.org/10.3390/microorganisms6010011 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Köck, Robin
Siemer, Philipp
Esser, Jutta
Kampmeier, Stefanie
Berends, Matthijs S.
Glasner, Corinna
Arends, Jan P.
Becker, Karsten
Friedrich, Alexander W.
Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title_full Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title_fullStr Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title_full_unstemmed Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title_short Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
title_sort defining multidrug resistance of gram-negative bacteria in the dutch–german border region—impact of national guidelines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874625/
https://www.ncbi.nlm.nih.gov/pubmed/29373498
http://dx.doi.org/10.3390/microorganisms6010011
work_keys_str_mv AT kockrobin definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT siemerphilipp definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT esserjutta definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT kampmeierstefanie definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT berendsmatthijss definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT glasnercorinna definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT arendsjanp definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT beckerkarsten definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines
AT friedrichalexanderw definingmultidrugresistanceofgramnegativebacteriainthedutchgermanborderregionimpactofnationalguidelines