The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota,...

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Autores principales: Enaud, Raphaël, Vandenborght, Louise-Eva, Coron, Noémie, Bazin, Thomas, Prevel, Renaud, Schaeverbeke, Thierry, Berger, Patrick, Fayon, Michael, Lamireau, Thierry, Delhaes, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874636/
https://www.ncbi.nlm.nih.gov/pubmed/29522426
http://dx.doi.org/10.3390/microorganisms6010022
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author Enaud, Raphaël
Vandenborght, Louise-Eva
Coron, Noémie
Bazin, Thomas
Prevel, Renaud
Schaeverbeke, Thierry
Berger, Patrick
Fayon, Michael
Lamireau, Thierry
Delhaes, Laurence
author_facet Enaud, Raphaël
Vandenborght, Louise-Eva
Coron, Noémie
Bazin, Thomas
Prevel, Renaud
Schaeverbeke, Thierry
Berger, Patrick
Fayon, Michael
Lamireau, Thierry
Delhaes, Laurence
author_sort Enaud, Raphaël
collection PubMed
description In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.
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spelling pubmed-58746362018-04-02 The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis Enaud, Raphaël Vandenborght, Louise-Eva Coron, Noémie Bazin, Thomas Prevel, Renaud Schaeverbeke, Thierry Berger, Patrick Fayon, Michael Lamireau, Thierry Delhaes, Laurence Microorganisms Review In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research. MDPI 2018-03-09 /pmc/articles/PMC5874636/ /pubmed/29522426 http://dx.doi.org/10.3390/microorganisms6010022 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Enaud, Raphaël
Vandenborght, Louise-Eva
Coron, Noémie
Bazin, Thomas
Prevel, Renaud
Schaeverbeke, Thierry
Berger, Patrick
Fayon, Michael
Lamireau, Thierry
Delhaes, Laurence
The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title_full The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title_fullStr The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title_full_unstemmed The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title_short The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
title_sort mycobiome: a neglected component in the microbiota-gut-brain axis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874636/
https://www.ncbi.nlm.nih.gov/pubmed/29522426
http://dx.doi.org/10.3390/microorganisms6010022
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