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Development of Zika Virus Vaccines
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874648/ https://www.ncbi.nlm.nih.gov/pubmed/29346287 http://dx.doi.org/10.3390/vaccines6010007 |
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author | Makhluf, Huda Shresta, Sujan |
author_facet | Makhluf, Huda Shresta, Sujan |
author_sort | Makhluf, Huda |
collection | PubMed |
description | Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines. |
format | Online Article Text |
id | pubmed-5874648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58746482018-04-02 Development of Zika Virus Vaccines Makhluf, Huda Shresta, Sujan Vaccines (Basel) Review Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged as a global threat following the most recent outbreak in Brazil in 2015. ZIKV infection of pregnant women is associated with fetal abnormalities such as microcephaly, and infection of adults can lead to Guillain–Barré syndrome, an autoimmune disease characterized by neurological deficits. Although there are currently licensed vaccines for other flaviviruses, there remains an urgent need for preventative vaccines against ZIKV infection. Herein we describe the current efforts to accelerate the development of ZIKV vaccines using various platforms, including live attenuated virus, inactivated virus, DNA and RNA, viral vectors, and in silico-predicted immunogenic viral epitopes. Many of these approaches have leveraged lessons learned from past experience with Dengue and other flavivirus vaccines. MDPI 2018-01-18 /pmc/articles/PMC5874648/ /pubmed/29346287 http://dx.doi.org/10.3390/vaccines6010007 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Makhluf, Huda Shresta, Sujan Development of Zika Virus Vaccines |
title | Development of Zika Virus Vaccines |
title_full | Development of Zika Virus Vaccines |
title_fullStr | Development of Zika Virus Vaccines |
title_full_unstemmed | Development of Zika Virus Vaccines |
title_short | Development of Zika Virus Vaccines |
title_sort | development of zika virus vaccines |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874648/ https://www.ncbi.nlm.nih.gov/pubmed/29346287 http://dx.doi.org/10.3390/vaccines6010007 |
work_keys_str_mv | AT makhlufhuda developmentofzikavirusvaccines AT shrestasujan developmentofzikavirusvaccines |