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The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia

Background: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50–70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical mo...

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Autores principales: Tosti, Giulio, Iacobone, Anna Daniela, Preti, Eleonora Petra, Vaccari, Sabina, Barisani, Alessia, Pennacchioli, Elisabetta, Cantisani, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874670/
https://www.ncbi.nlm.nih.gov/pubmed/29393881
http://dx.doi.org/10.3390/biomedicines6010013
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author Tosti, Giulio
Iacobone, Anna Daniela
Preti, Eleonora Petra
Vaccari, Sabina
Barisani, Alessia
Pennacchioli, Elisabetta
Cantisani, Carmen
author_facet Tosti, Giulio
Iacobone, Anna Daniela
Preti, Eleonora Petra
Vaccari, Sabina
Barisani, Alessia
Pennacchioli, Elisabetta
Cantisani, Carmen
author_sort Tosti, Giulio
collection PubMed
description Background: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50–70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical morbidities related to extensive surgery, several less aggressive treatment modalities have been proposed since the late 1970s. Photodynamic therapy is an effective and safe treatment for cutaneous non-melanoma skin cancer, with favorable cosmetic outcomes. Methods: in the present paper, the results of selected studies on photodynamic therapy in the treatment of vulvar intraepithelial neoplasia are reported and discussed. Results: Overall, complete histological response rates ranged between 20% and 67% and symptom response rates ranged between 52% and 89% according to different studies and case series. Conclusions: the real benefit of photodynamic therapy in the setting of vulvar intraepithelial neoplasia lies in its ability to treat multi-focal disease with minimal tissue destruction, preservation of vulvar anatomy and excellent cosmetic outcomes. These properties explain why photodynamic therapy is an attractive option for vulvar intraepithelial neoplasia treatment.
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spelling pubmed-58746702018-03-29 The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia Tosti, Giulio Iacobone, Anna Daniela Preti, Eleonora Petra Vaccari, Sabina Barisani, Alessia Pennacchioli, Elisabetta Cantisani, Carmen Biomedicines Review Background: vulvar intraepithelial neoplasia is a non-invasive precursor lesion found in 50–70% of patients affected by vulvar squamous cell carcinoma. In the past, radical surgery was the standard treatment for vulvar intraepithelial neoplasia, however, considering the psychological and physical morbidities related to extensive surgery, several less aggressive treatment modalities have been proposed since the late 1970s. Photodynamic therapy is an effective and safe treatment for cutaneous non-melanoma skin cancer, with favorable cosmetic outcomes. Methods: in the present paper, the results of selected studies on photodynamic therapy in the treatment of vulvar intraepithelial neoplasia are reported and discussed. Results: Overall, complete histological response rates ranged between 20% and 67% and symptom response rates ranged between 52% and 89% according to different studies and case series. Conclusions: the real benefit of photodynamic therapy in the setting of vulvar intraepithelial neoplasia lies in its ability to treat multi-focal disease with minimal tissue destruction, preservation of vulvar anatomy and excellent cosmetic outcomes. These properties explain why photodynamic therapy is an attractive option for vulvar intraepithelial neoplasia treatment. MDPI 2018-02-02 /pmc/articles/PMC5874670/ /pubmed/29393881 http://dx.doi.org/10.3390/biomedicines6010013 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tosti, Giulio
Iacobone, Anna Daniela
Preti, Eleonora Petra
Vaccari, Sabina
Barisani, Alessia
Pennacchioli, Elisabetta
Cantisani, Carmen
The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title_full The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title_fullStr The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title_full_unstemmed The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title_short The Role of Photodynamic Therapy in the Treatment of Vulvar Intraepithelial Neoplasia
title_sort role of photodynamic therapy in the treatment of vulvar intraepithelial neoplasia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874670/
https://www.ncbi.nlm.nih.gov/pubmed/29393881
http://dx.doi.org/10.3390/biomedicines6010013
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