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Improved Syntheses of the mGlu(5) Antagonists MMPEP and MTEP Using Sonogashira Cross-Coupling

The Sonogashira cross-coupling, a key step in the syntheses of the mGlu(5) antagonists MMPEP and MTEP, provided an improved three-step method for the preparation of MMPEP in 62% overall yield. Using Spartan molecular modeling kit an explanation for the failure to employ analogues method in the synth...

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Detalles Bibliográficos
Autores principales:	Mu, Boshuai, Mu, Linjing, Schibli, Roger, Ametamey, Simon M., Milicevic Sephton, Selena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874720/ https://www.ncbi.nlm.nih.gov/pubmed/29461503 http://dx.doi.org/10.3390/ph11010024

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