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Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen
Listeria monocytogenes is a foodborne pathogen that can cause febrile gastroenteritis in healthy subjects and systemic infections in immunocompromised individuals. Despite the high prevalence of L. monocytogenes in the environment and frequent contamination of uncooked meat and poultry products, inf...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874727/ https://www.ncbi.nlm.nih.gov/pubmed/29271903 http://dx.doi.org/10.3390/pathogens7010001 |
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author | Becattini, Simone Pamer, Eric G. |
author_facet | Becattini, Simone Pamer, Eric G. |
author_sort | Becattini, Simone |
collection | PubMed |
description | Listeria monocytogenes is a foodborne pathogen that can cause febrile gastroenteritis in healthy subjects and systemic infections in immunocompromised individuals. Despite the high prevalence of L. monocytogenes in the environment and frequent contamination of uncooked meat and poultry products, infections with this pathogen are relatively uncommon, suggesting that protective defenses in the general population are effective. In the mammalian gastrointestinal tract, a variety of defense mechanisms prevent L. monocytogenes growth, epithelial penetration and systemic dissemination. Among these defenses, colonization resistance mediated by the gut microbiota is crucial in protection against a range of intestinal pathogens, including L. monocytogenes. Here we review defined mechanisms of defense against L. monocytogenes in the lumen of the gastro-intestinal tract, with particular emphasis on protection conferred by the autochthonous microbiota. We suggest that selected probiotic species derived from the microbiota may be developed for eventual clinical use to enhance resistance against L. monocytogenes infections. |
format | Online Article Text |
id | pubmed-5874727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58747272018-04-02 Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen Becattini, Simone Pamer, Eric G. Pathogens Review Listeria monocytogenes is a foodborne pathogen that can cause febrile gastroenteritis in healthy subjects and systemic infections in immunocompromised individuals. Despite the high prevalence of L. monocytogenes in the environment and frequent contamination of uncooked meat and poultry products, infections with this pathogen are relatively uncommon, suggesting that protective defenses in the general population are effective. In the mammalian gastrointestinal tract, a variety of defense mechanisms prevent L. monocytogenes growth, epithelial penetration and systemic dissemination. Among these defenses, colonization resistance mediated by the gut microbiota is crucial in protection against a range of intestinal pathogens, including L. monocytogenes. Here we review defined mechanisms of defense against L. monocytogenes in the lumen of the gastro-intestinal tract, with particular emphasis on protection conferred by the autochthonous microbiota. We suggest that selected probiotic species derived from the microbiota may be developed for eventual clinical use to enhance resistance against L. monocytogenes infections. MDPI 2017-12-22 /pmc/articles/PMC5874727/ /pubmed/29271903 http://dx.doi.org/10.3390/pathogens7010001 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Becattini, Simone Pamer, Eric G. Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen |
title | Multifaceted Defense against Listeria
monocytogenes in the Gastro-Intestinal Lumen |
title_full | Multifaceted Defense against Listeria
monocytogenes in the Gastro-Intestinal Lumen |
title_fullStr | Multifaceted Defense against Listeria
monocytogenes in the Gastro-Intestinal Lumen |
title_full_unstemmed | Multifaceted Defense against Listeria
monocytogenes in the Gastro-Intestinal Lumen |
title_short | Multifaceted Defense against Listeria
monocytogenes in the Gastro-Intestinal Lumen |
title_sort | multifaceted defense against listeria
monocytogenes in the gastro-intestinal lumen |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874727/ https://www.ncbi.nlm.nih.gov/pubmed/29271903 http://dx.doi.org/10.3390/pathogens7010001 |
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