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Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans

The incidence of human infections caused by the opportunistic fungal pathogen Candida albicans is on the rise due to increasing numbers of immunosuppressed patients. The importance of the immune system in preventing overgrowth of the colonizing fungus and thereby limiting infection is well recognize...

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Autores principales: Braunsdorf, Christina, LeibundGut-Landmann, Salomé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874737/
https://www.ncbi.nlm.nih.gov/pubmed/29342100
http://dx.doi.org/10.3390/pathogens7010011
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author Braunsdorf, Christina
LeibundGut-Landmann, Salomé
author_facet Braunsdorf, Christina
LeibundGut-Landmann, Salomé
author_sort Braunsdorf, Christina
collection PubMed
description The incidence of human infections caused by the opportunistic fungal pathogen Candida albicans is on the rise due to increasing numbers of immunosuppressed patients. The importance of the immune system in preventing overgrowth of the colonizing fungus and thereby limiting infection is well recognized and host protective mechanisms widely investigated. Only recently, it was recognized that the natural diversity in the fungal species could also influence the outcome of the interaction between the fungus and the host. C. albicans strain-specific differences are complex and their regulation at the genomic, genetic, and epigenetic level and by environmental factors is only partially understood. In this review, we provide an overview of the natural diversity of C. albicans and discuss how it impacts host-fungal interactions and thereby affects the balance between commensalism versus disease.
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spelling pubmed-58747372018-04-02 Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans Braunsdorf, Christina LeibundGut-Landmann, Salomé Pathogens Review The incidence of human infections caused by the opportunistic fungal pathogen Candida albicans is on the rise due to increasing numbers of immunosuppressed patients. The importance of the immune system in preventing overgrowth of the colonizing fungus and thereby limiting infection is well recognized and host protective mechanisms widely investigated. Only recently, it was recognized that the natural diversity in the fungal species could also influence the outcome of the interaction between the fungus and the host. C. albicans strain-specific differences are complex and their regulation at the genomic, genetic, and epigenetic level and by environmental factors is only partially understood. In this review, we provide an overview of the natural diversity of C. albicans and discuss how it impacts host-fungal interactions and thereby affects the balance between commensalism versus disease. MDPI 2018-01-17 /pmc/articles/PMC5874737/ /pubmed/29342100 http://dx.doi.org/10.3390/pathogens7010011 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Braunsdorf, Christina
LeibundGut-Landmann, Salomé
Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title_full Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title_fullStr Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title_full_unstemmed Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title_short Modulation of the Fungal-Host Interaction by the Intra-Species Diversity of C. albicans
title_sort modulation of the fungal-host interaction by the intra-species diversity of c. albicans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874737/
https://www.ncbi.nlm.nih.gov/pubmed/29342100
http://dx.doi.org/10.3390/pathogens7010011
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