Cargando…

The Structure of PrP(Sc) Prions

PrP(Sc) (scrapie isoform of the prion protein) prions are the infectious agent behind diseases such as Creutzfeldt–Jakob disease in humans, bovine spongiform encephalopathy in cattle, chronic wasting disease in cervids (deer, elk, moose, and reindeer), as well as goat and sheep scrapie. PrP(Sc) is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wille, Holger, Requena, Jesús R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874746/ https://www.ncbi.nlm.nih.gov/pubmed/29414853 http://dx.doi.org/10.3390/pathogens7010020

Ejemplares similares

The prion 2018 round tables (I): the structure of PrP(Sc)
por: Baskakov, Ilia V., et al.
Publicado: (2019)

Infectivity-associated PrP(Sc) and disease duration-associated PrP(Sc) of mouse BSE prions
por: Miyazawa, Kohtaro, et al.
Publicado: (2015)

Heterogeneity of Abnormal Prion Protein (PrP(Sc)) in Murine Scrapie Prions Determined by PrP(Sc)-Specific Monoclonal Antibodies
por: USHIKI-KAKU, Yuko, et al.
Publicado: (2013)

Propagation of PrP(Sc) in mice reveals impact of aggregate composition on prion disease pathogenesis
por: Chang, Sheng Chun, et al.
Publicado: (2023)

PK-sensitive PrP(Sc) Is Infectious and Shares Basic Structural Features with PK-resistant PrP(Sc)
por: Sajnani, Gustavo, et al.
Publicado: (2012)

Exploration of the Main Sites for the Transformation of Normal Prion Protein (PrP(C)) into Pathogenic Prion Protein (PrP(sc))
por: Liu, Xi-Lin, et al.
Publicado: (2017)

PrP(Sc) formation and clearance as determinants of prion tropism
por: Shikiya, Ronald A., et al.
Publicado: (2017)

Recombinant PrP(Sc) shares structural features with brain-derived PrP(Sc): Insights from limited proteolysis
por: Sevillano, Alejandro M., et al.
Publicado: (2018)

Anti-Prion Drug mPPIg5 Inhibits PrP(C) Conversion to PrP(Sc)
por: McCarthy, James M., et al.
Publicado: (2013)

Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
por: Srivastava, Saurabh, et al.
Publicado: (2018)

The Octarepeat Region of the Prion Protein Is Conformationally Altered in PrP(Sc)
por: Yam, Alice Y., et al.
Publicado: (2010)

PrP(Sc)-Specific Antibodies with the Ability to Immunodetect Prion Oligomers
por: Tayebi, Mourad, et al.
Publicado: (2011)

Modeling PrP(Sc) Generation Through Deformed Templating
por: Spagnolli, Giovanni, et al.
Publicado: (2020)

Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)
por: Kim, Chae, et al.
Publicado: (2012)

Glimepiride Reduces the Expression of PrP(C), Prevents PrP(Sc) Formation and Protects against Prion Mediated Neurotoxicity
por: Bate, Clive, et al.
Publicado: (2009)

A Camelid Anti-PrP Antibody Abrogates PrP(Sc) Replication in Prion-Permissive Neuroblastoma Cell Lines
por: Jones, Daryl Rhys, et al.
Publicado: (2010)

Identifying critical sites of PrP(c)-PrP(Sc) interaction in prion-infected cells by dominant-negative inhibition
por: Taguchi, Yuzuru, et al.
Publicado: (2013)

Heterogeneity of the Abnormal Prion Protein (PrP(Sc)) of the Chandler Scrapie Strain
por: Kasai, Kazuo, et al.
Publicado: (2013)

Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)
por: Lakkaraju, Asvin K. K., et al.
Publicado: (2022)

How do PrP(Sc) Prions Spread between Host Species, and within Hosts?
por: Mabbott, Neil A.
Publicado: (2017)

Prion acute synaptotoxicity is largely driven by protease-resistant PrP(Sc) species
por: Foliaki, Simote Totauhelotu, et al.
Publicado: (2018)

Analysis of Prion Strains by PrP(Sc) Profiling in Sporadic Creutzfeldt–Jakob Disease
por: Schoch, Gaby, et al.
Publicado: (2006)

PrP(Sc )spreading patterns in the brain of sheep linked to different prion types
por: Wemheuer, Wiebke M, et al.
Publicado: (2011)

Disulfide-crosslink scanning reveals prion–induced conformational changes and prion strain–specific structures of the pathological prion protein PrP(Sc)
por: Taguchi, Yuzuru, et al.
Publicado: (2018)

Prion protein (PrP) gene-knockout cell lines: insight into functions of the PrP
por: Sakudo, Akikazu, et al.
Publicado: (2015)

Detection of Pathognomonic Biomarker PrP(Sc) and the Contribution of Cell Free-Amplification Techniques to the Diagnosis of Prion Diseases
por: Eraña, Hasier, et al.
Publicado: (2020)

Prion protein—Semisynthetic prion protein (PrP) variants with posttranslational modifications
por: Hackl, Stefanie, et al.
Publicado: (2019)

Accumulation of Pathological Prion Protein PrP(Sc) in the Skin of Animals with Experimental and Natural Scrapie
por: Thomzig, Achim, et al.
Publicado: (2007)

Prion protein amino acid sequence influences formation of authentic synthetic PrP(Sc)
por: Block, Alyssa J., et al.
Publicado: (2023)

The N-Terminal Sequence of Prion Protein Consists an Epitope Specific to the Abnormal Isoform of Prion Protein (PrP(Sc))
por: Masujin, Kentaro, et al.
Publicado: (2013)

The Functional Role of Prion Protein (PrP(C)) on Autophagy
por: Shin, Hae-Young, et al.
Publicado: (2013)

The Multifaceted Functions of Prion Protein (PrP(C)) in Cancer
por: Abi Nahed, Roland, et al.
Publicado: (2023)

Sialylation of Prion Protein Controls the Rate of Prion Amplification, the Cross-Species Barrier, the Ratio of PrP(Sc) Glycoform and Prion Infectivity
por: Katorcha, Elizaveta, et al.
Publicado: (2014)

PrP(Sc )accumulation in neuronal plasma membranes links Notch-1 activation to dendritic degeneration in prion diseases
por: DeArmond, Stephen J, et al.
Publicado: (2010)

The First Evaluation of Proteinase K-Resistant Prion Protein (PrP(Sc)) in Korean Appendix Specimens
por: Won, Sae-Young, et al.
Publicado: (2022)

The structure of the infectious prion protein: Experimental data and molecular models
por: Requena, Jesús R, et al.
Publicado: (2014)

Mammalian prion propagation in PrP transgenic Drosophila
por: Thackray, Alana M, et al.
Publicado: (2018)

The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro
por: Honda, Ryo P., et al.
Publicado: (2017)

PrP Expression, PrP(Sc) Accumulation and Innervation of Splenic Compartments in Sheep Experimentally Infected with Scrapie
por: Sørby, Randi, et al.
Publicado: (2009)

Species and Strain Glycosylation Patterns of PrP(Sc)
por: Xanthopoulos, Konstantinos, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_uk2for47nderf2veoe477v6fdd