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Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment

Since urinary insecticide metabolites are commonly used as biomarkers of exposure, it is important that we quantify whether insecticides degrade in food and beverages in order to better perform risk assessment. This study was designed to quantify degradation of organophosphorus and pyrethroid insect...

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Detalles Bibliográficos
Autores principales: Radford, Samantha A., Panuwet, Parinya, Hunter, Ronald E., Barr, Dana Boyd, Ryan, P. Barry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874784/
https://www.ncbi.nlm.nih.gov/pubmed/29393904
http://dx.doi.org/10.3390/toxics6010011
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author Radford, Samantha A.
Panuwet, Parinya
Hunter, Ronald E.
Barr, Dana Boyd
Ryan, P. Barry
author_facet Radford, Samantha A.
Panuwet, Parinya
Hunter, Ronald E.
Barr, Dana Boyd
Ryan, P. Barry
author_sort Radford, Samantha A.
collection PubMed
description Since urinary insecticide metabolites are commonly used as biomarkers of exposure, it is important that we quantify whether insecticides degrade in food and beverages in order to better perform risk assessment. This study was designed to quantify degradation of organophosphorus and pyrethroid insecticides in beverages. Purified water, white grape juice, orange juice, and red wine were fortified with 500 ng/mL diazinon, malathion, chlorpyrifos, permethrin, cyfluthrin, cypermethrin, and deltamethrin, and aliquots were extracted several times over a 15-day storage period at 2.5 °C. Overall, statistically significant loss of at least one insecticide was observed in each matrix, and at least five out of seven insecticides demonstrated a statistically significant loss in all matrices except orange juice. An investigation of an alternative mechanism of insecticide loss—adsorption onto the glass surface of the storage jars—was carried out, which indicated that this mechanism of loss is insignificant. Results of this work suggest that insecticides degrade in these beverages, and this degradation may lead to pre-existing insecticide degradates in the beverages, suggesting that caution should be exercised when using urinary insecticide metabolites to assess exposure and risk.
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spelling pubmed-58747842018-04-02 Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment Radford, Samantha A. Panuwet, Parinya Hunter, Ronald E. Barr, Dana Boyd Ryan, P. Barry Toxics Article Since urinary insecticide metabolites are commonly used as biomarkers of exposure, it is important that we quantify whether insecticides degrade in food and beverages in order to better perform risk assessment. This study was designed to quantify degradation of organophosphorus and pyrethroid insecticides in beverages. Purified water, white grape juice, orange juice, and red wine were fortified with 500 ng/mL diazinon, malathion, chlorpyrifos, permethrin, cyfluthrin, cypermethrin, and deltamethrin, and aliquots were extracted several times over a 15-day storage period at 2.5 °C. Overall, statistically significant loss of at least one insecticide was observed in each matrix, and at least five out of seven insecticides demonstrated a statistically significant loss in all matrices except orange juice. An investigation of an alternative mechanism of insecticide loss—adsorption onto the glass surface of the storage jars—was carried out, which indicated that this mechanism of loss is insignificant. Results of this work suggest that insecticides degrade in these beverages, and this degradation may lead to pre-existing insecticide degradates in the beverages, suggesting that caution should be exercised when using urinary insecticide metabolites to assess exposure and risk. MDPI 2018-02-02 /pmc/articles/PMC5874784/ /pubmed/29393904 http://dx.doi.org/10.3390/toxics6010011 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Radford, Samantha A.
Panuwet, Parinya
Hunter, Ronald E.
Barr, Dana Boyd
Ryan, P. Barry
Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title_full Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title_fullStr Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title_full_unstemmed Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title_short Degradation of Organophosphorus and Pyrethroid Insecticides in Beverages: Implications for Risk Assessment
title_sort degradation of organophosphorus and pyrethroid insecticides in beverages: implications for risk assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874784/
https://www.ncbi.nlm.nih.gov/pubmed/29393904
http://dx.doi.org/10.3390/toxics6010011
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