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Pharmacokinetics and Pharmacodynamics of (S)-Ketoprofen Co-Administered with Caffeine: A Preclinical Study in Arthritic Rats

The purpose of the present study was to determine whether caffeine modifies the pharmacokinetics and pharmacodynamics of (S)-ketoprofen following oral administration in a gout-type pain model. 3.2 mg/kg of (S)-ketoprofen alone and combined with 17.8 mg/kg of caffeine were administered to Wistar rats...

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Detalles Bibliográficos
Autores principales:	Medina-López, Raúl, Vara-Gama, Nancy, Soria-Arteche, Olivia, Moreno-Rocha, Luis A., López-Muñoz, Francisco J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874833/ https://www.ncbi.nlm.nih.gov/pubmed/29373537 http://dx.doi.org/10.3390/pharmaceutics10010020

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