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Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update

The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential...

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Autores principales: Mohn, Emily S., Kern, Hua J., Saltzman, Edward, Mitmesser, Susan H., McKay, Diane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874849/
https://www.ncbi.nlm.nih.gov/pubmed/29558445
http://dx.doi.org/10.3390/pharmaceutics10010036
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author Mohn, Emily S.
Kern, Hua J.
Saltzman, Edward
Mitmesser, Susan H.
McKay, Diane L.
author_facet Mohn, Emily S.
Kern, Hua J.
Saltzman, Edward
Mitmesser, Susan H.
McKay, Diane L.
author_sort Mohn, Emily S.
collection PubMed
description The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential drug–nutrient interactions is quite limited. A comprehensive, updated review of the potential drug–nutrient interactions with chronic use of the most often prescribed medications for commonly diagnosed conditions among the general U.S. adult population is presented. For the majority of the interactions described in this paper, more high-quality intervention trials are needed to better understand their clinical importance and potential consequences. A number of these studies have identified potential risk factors that may make certain populations more susceptible, but guidelines on how to best manage and/or prevent drug-induced nutrient inadequacies are lacking. Although widespread supplementation is not currently recommended, it is important to ensure at-risk patients reach their recommended intakes for vitamins and minerals. In conjunction with an overall healthy diet, appropriate dietary supplementation may be a practical and efficacious way to maintain or improve micronutrient status in patients at risk of deficiencies, such as those taking medications known to compromise nutritional status. The summary evidence presented in this review will help inform future research efforts and, ultimately, guide recommendations for patient care.
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spelling pubmed-58748492018-04-02 Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update Mohn, Emily S. Kern, Hua J. Saltzman, Edward Mitmesser, Susan H. McKay, Diane L. Pharmaceutics Review The long-term use of prescription and over-the-counter drugs can induce subclinical and clinically relevant micronutrient deficiencies, which may develop gradually over months or even years. Given the large number of medications currently available, the number of research studies examining potential drug–nutrient interactions is quite limited. A comprehensive, updated review of the potential drug–nutrient interactions with chronic use of the most often prescribed medications for commonly diagnosed conditions among the general U.S. adult population is presented. For the majority of the interactions described in this paper, more high-quality intervention trials are needed to better understand their clinical importance and potential consequences. A number of these studies have identified potential risk factors that may make certain populations more susceptible, but guidelines on how to best manage and/or prevent drug-induced nutrient inadequacies are lacking. Although widespread supplementation is not currently recommended, it is important to ensure at-risk patients reach their recommended intakes for vitamins and minerals. In conjunction with an overall healthy diet, appropriate dietary supplementation may be a practical and efficacious way to maintain or improve micronutrient status in patients at risk of deficiencies, such as those taking medications known to compromise nutritional status. The summary evidence presented in this review will help inform future research efforts and, ultimately, guide recommendations for patient care. MDPI 2018-03-20 /pmc/articles/PMC5874849/ /pubmed/29558445 http://dx.doi.org/10.3390/pharmaceutics10010036 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mohn, Emily S.
Kern, Hua J.
Saltzman, Edward
Mitmesser, Susan H.
McKay, Diane L.
Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title_full Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title_fullStr Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title_full_unstemmed Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title_short Evidence of Drug–Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update
title_sort evidence of drug–nutrient interactions with chronic use of commonly prescribed medications: an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874849/
https://www.ncbi.nlm.nih.gov/pubmed/29558445
http://dx.doi.org/10.3390/pharmaceutics10010036
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