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The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes

Botulinum neurotoxin (BoNT) is the causative agent of botulism and a widely used pharmaceutical to treat a variety of neurological diseases. BoNTs are 150-kDa protein toxins organized into heavy chain (HC) and light chain (LC) domains linked by a disulfide bond. The HC selectively binds to neurons a...

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Detalles Bibliográficos
Autores principales:	Pellett, Sabine, Bradshaw, Marite, Tepp, William H., Pier, Christina L., Whitemarsh, Regina C. M., Chen, Chen, Barbieri, Joseph T., Johnson, Eric A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874905/ https://www.ncbi.nlm.nih.gov/pubmed/29588398 http://dx.doi.org/10.1128/mBio.00089-18

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