Cargando…

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island. These genotoxic metabolites are produced by pks-encoded peptide-polyketide synthases as inactive prodrugs called precolibactins,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bossuet-Greif, Nadège, Vignard, Julien, Taieb, Frédéric, Mirey, Gladys, Dubois, Damien, Petit, Claude, Oswald, Eric, Nougayrède, Jean-Philippe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874909/ https://www.ncbi.nlm.nih.gov/pubmed/29559578 http://dx.doi.org/10.1128/mBio.02393-17

Ejemplares similares

The Polyphosphate Kinase of Escherichia coli Is Required for Full Production of the Genotoxin Colibactin
por: Tang-Fichaux, Min, et al.
Publicado: (2020)

The Polyamine Spermidine Modulates the Production of the Bacterial Genotoxin Colibactin
por: Chagneau, Camille V., et al.
Publicado: (2019)

Interplay between Siderophores and Colibactin Genotoxin Biosynthetic Pathways in Escherichia coli
por: Martin, Patricia, et al.
Publicado: (2013)

Oxygen concentration modulates colibactin production
por: Bossuet, Nadège, et al.
Publicado: (2023)

The Genotoxin Colibactin Shapes Gut Microbiota in Mice
por: Tronnet, Sophie, et al.
Publicado: (2020)

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population
por: Auvray, Frédéric, et al.
Publicado: (2021)

D-Serine reduces the expression of the cytopathic genotoxin colibactin
por: Hallam, Jennifer C., et al.
Publicado: (2023)

ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
por: Wallenstein, Alexander, et al.
Publicado: (2020)

The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors
por: Dougherty, Michael W., et al.
Publicado: (2023)

Structural basis of the amidase ClbL central to the biosynthesis of the genotoxin colibactin
por: Tripathi, Prabhanshu, et al.
Publicado: (2023)

Erratum for Wallenstein et al., “ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli”
por: Wallenstein, Alexander, et al.
Publicado: (2020)

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells
por: Secher, Thomas, et al.
Publicado: (2013)

Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?
por: Tang-Fichaux, Min, et al.
Publicado: (2021)

A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917
por: Nougayrède, Jean-Philippe, et al.
Publicado: (2021)

Deciphering the interplay between the genotoxic and probiotic activities of Escherichia coli Nissle 1917
por: Massip, Clémence, et al.
Publicado: (2019)

Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition
por: Wong, Jun Jie, et al.
Publicado: (2022)

The Cytolethal Distending Toxin Effects on Mammalian Cells: A DNA Damage Perspective
por: Bezine, Elisabeth, et al.
Publicado: (2014)

Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety
por: Bian, Xiaoying, et al.
Publicado: (2015)

Around and beyond 53BP1 Nuclear Bodies
por: Fernandez-Vidal, Anne, et al.
Publicado: (2017)

Cytolethal Distending Toxin Subunit B: A Review of Structure–Function Relationship
por: Pons, Benoît J., et al.
Publicado: (2019)

Uncoupling the Hsp90 and DnaK chaperone activities revealed the in vivo relevance of their collaboration in bacteria
por: Corteggiani, Marie, et al.
Publicado: (2022)

Cycle Inhibiting Factors (Cifs): Cyclomodulins That Usurp the Ubiquitin-Dependent Degradation Pathway of Host Cells
por: Taieb, Frédéric, et al.
Publicado: (2011)

Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli
por: Rehm, Nadine, et al.
Publicado: (2022)

High Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
por: Buc, Emmanuel, et al.
Publicado: (2013)

Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response
por: Pons, Benoît J., et al.
Publicado: (2021)

Functional Study of Haemophilus ducreyi Cytolethal Distending Toxin Subunit B
por: Pons, Benoît J., et al.
Publicado: (2020)

Genotoxins: The Mechanistic Links between Escherichia coli and Colorectal Cancer
por: Wang, Ya, et al.
Publicado: (2023)

The colibactin warhead crosslinks DNA
por: Vizcaino, Maria I., et al.
Publicado: (2015)

Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis
por: Graillot, Vanessa, et al.
Publicado: (2016)

DNA alkylation and interstrand cross-linking by treosulfan
por: Hartley, J A, et al.
Publicado: (1999)

Colibactin: More Than a New Bacterial Toxin
por: Faïs, Tiphanie, et al.
Publicado: (2018)

Shining a Light on Colibactin Biology
por: Dougherty, Michael W., et al.
Publicado: (2021)

Uropathogenic E. coli induces DNA damage in the bladder
por: Chagneau, Camille V., et al.
Publicado: (2021)

Transplacental transfer of genotoxins and transplacental carcinogenesis.
por: Autrup, H
Publicado: (1993)

Delivery, structure, and function of bacterial genotoxins
por: Du, Liaoqi, et al.
Publicado: (2022)

Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms
por: Bezine, Elisabeth, et al.
Publicado: (2016)

Dairy By-Products and Lactoferrin Exert Antioxidant and Antigenotoxic Activity on Intestinal and Hepatic Cells
por: Abad, Inés, et al.
Publicado: (2023)

Insights into evolution and coexistence of the colibactin- and yersiniabactin secondary metabolite determinants in enterobacterial populations
por: Wami, Haleluya, et al.
Publicado: (2021)

The bacterial toxin colibactin triggers prophage induction
por: Silpe, Justin E., et al.
Publicado: (2022)

Contributions of DNA interstrand cross-links to aging of cells and organisms
por: Grillari, Johannes, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_9m07m7o4s6nduttr00ckolgrjt