HIV-1 Uncoating and Reverse Transcription Require eEF1A Binding to Surface-Exposed Acidic Residues of the Reverse Transcriptase Thumb Domain

Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding host cell factors have been convincingly shown...

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Detalles Bibliográficos
Autores principales: Rawle, Daniel J., Li, Dongsheng, Swedberg, Joakim E., Wang, Lu, Soares, Dinesh C., Harrich, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874916/
https://www.ncbi.nlm.nih.gov/pubmed/29588400
http://dx.doi.org/10.1128/mBio.00316-18

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