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Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams

Full Monte Carlo (FMC) calculation of dose distribution has been recognized to have superior accuracy, compared with the pencil beam algorithm (PBA). However, since the FMC methods require long calculation time, it is difficult to apply them to routine treatment planning at present. In order to impr...

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Autores principales: Mizutani, Shohei, Takada, Yoshihisa, Kohno, Ryosuke, Hotta, Kenji, Tansho, Ryohei, Akimoto, Tetsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874961/
https://www.ncbi.nlm.nih.gov/pubmed/27074456
http://dx.doi.org/10.1120/jacmp.v17i2.5747
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author Mizutani, Shohei
Takada, Yoshihisa
Kohno, Ryosuke
Hotta, Kenji
Tansho, Ryohei
Akimoto, Tetsuo
author_facet Mizutani, Shohei
Takada, Yoshihisa
Kohno, Ryosuke
Hotta, Kenji
Tansho, Ryohei
Akimoto, Tetsuo
author_sort Mizutani, Shohei
collection PubMed
description Full Monte Carlo (FMC) calculation of dose distribution has been recognized to have superior accuracy, compared with the pencil beam algorithm (PBA). However, since the FMC methods require long calculation time, it is difficult to apply them to routine treatment planning at present. In order to improve the situation, a simplified Monte Carlo (SMC) method has been introduced to the dose kernel calculation applicable to dose optimization procedure for the proton pencil beam scanning. We have evaluated accuracy of the SMC calculation by comparing a result of the dose kernel calculation using the SMC method with that using the FMC method in an inhomogeneous phantom. The dose distribution obtained by the SMC method was in good agreement with that obtained by the FMC method. To assess the usefulness of SMC calculation in clinical situations, we have compared results of the dose calculation using the SMC with those using the PBA method for three clinical cases of tumor treatment. The dose distributions calculated with the PBA dose kernels appear to be homogeneous in the planning target volumes (PTVs). In practice, the dose distributions calculated with the SMC dose kernels with the spot weights optimized with the PBA method show largely inhomogeneous dose distributions in the PTVs, while those with the spot weights optimized with the SMC method have moderately homogeneous distributions in the PTVs. Calculation using the SMC method is faster than that using the GEANT4 by three orders of magnitude. In addition, the graphic processing unit (GPU) boosts the calculation speed by 13 times for the treatment planning using the SMC method. Thence, the SMC method will be applicable to routine clinical treatment planning for reproduction of the complex dose distribution more accurately than the PBA method in a reasonably short time by use of the GPU‐based calculation engine. PACS number(s): 87.55.Gh
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spelling pubmed-58749612018-04-02 Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams Mizutani, Shohei Takada, Yoshihisa Kohno, Ryosuke Hotta, Kenji Tansho, Ryohei Akimoto, Tetsuo J Appl Clin Med Phys Radiation Oncology Physics Full Monte Carlo (FMC) calculation of dose distribution has been recognized to have superior accuracy, compared with the pencil beam algorithm (PBA). However, since the FMC methods require long calculation time, it is difficult to apply them to routine treatment planning at present. In order to improve the situation, a simplified Monte Carlo (SMC) method has been introduced to the dose kernel calculation applicable to dose optimization procedure for the proton pencil beam scanning. We have evaluated accuracy of the SMC calculation by comparing a result of the dose kernel calculation using the SMC method with that using the FMC method in an inhomogeneous phantom. The dose distribution obtained by the SMC method was in good agreement with that obtained by the FMC method. To assess the usefulness of SMC calculation in clinical situations, we have compared results of the dose calculation using the SMC with those using the PBA method for three clinical cases of tumor treatment. The dose distributions calculated with the PBA dose kernels appear to be homogeneous in the planning target volumes (PTVs). In practice, the dose distributions calculated with the SMC dose kernels with the spot weights optimized with the PBA method show largely inhomogeneous dose distributions in the PTVs, while those with the spot weights optimized with the SMC method have moderately homogeneous distributions in the PTVs. Calculation using the SMC method is faster than that using the GEANT4 by three orders of magnitude. In addition, the graphic processing unit (GPU) boosts the calculation speed by 13 times for the treatment planning using the SMC method. Thence, the SMC method will be applicable to routine clinical treatment planning for reproduction of the complex dose distribution more accurately than the PBA method in a reasonably short time by use of the GPU‐based calculation engine. PACS number(s): 87.55.Gh John Wiley and Sons Inc. 2016-03-08 /pmc/articles/PMC5874961/ /pubmed/27074456 http://dx.doi.org/10.1120/jacmp.v17i2.5747 Text en © 2016 The Authors. This is an open access article under the terms of the http://creativecommons.org/licenses/by/3.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Mizutani, Shohei
Takada, Yoshihisa
Kohno, Ryosuke
Hotta, Kenji
Tansho, Ryohei
Akimoto, Tetsuo
Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title_full Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title_fullStr Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title_full_unstemmed Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title_short Application of dose kernel calculation using a simplified Monte Carlo method to treatment plan for scanned proton beams
title_sort application of dose kernel calculation using a simplified monte carlo method to treatment plan for scanned proton beams
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5874961/
https://www.ncbi.nlm.nih.gov/pubmed/27074456
http://dx.doi.org/10.1120/jacmp.v17i2.5747
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