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Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

BACKGROUND: Tumor hypoxia-induced epithelial–mesenchymal transition (EMT) is critical in promoting cancer metastasis. We recently discovered a novel microtubule inhibitor, MPT0B098, that employs a novel antitumor mechanism. It destabilizes hypoxia-inducible factor (HIF)-1α mRNA by blocking the funct...

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Detalles Bibliográficos
Autores principales:	Tsai, I-Ting, Kuo, Ching-Chuan, Liou, Jing-Ping, Chang, Jang-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875002/ https://www.ncbi.nlm.nih.gov/pubmed/29592811 http://dx.doi.org/10.1186/s12929-018-0432-6

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