The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

BACKGROUND: Currently, several amyloid beta (Aβ) antibodies, including the protofibril selective antibody BAN2401, are in clinical trials. The murine version of BAN2401, mAb158, has previously been shown to lower the levels of pathogenic Aβ and prevent Aβ deposition in animal models of Alzheimer’s d...

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Detalles Bibliográficos
Autores principales: Söllvander, Sofia, Nikitidou, Elisabeth, Gallasch, Linn, Zyśk, Marlena, Söderberg, Linda, Sehlin, Dag, Lannfelt, Lars, Erlandsson, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875007/
https://www.ncbi.nlm.nih.gov/pubmed/29592816
http://dx.doi.org/10.1186/s12974-018-1134-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875007/
https://www.ncbi.nlm.nih.gov/pubmed/29592816
http://dx.doi.org/10.1186/s12974-018-1134-4

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